Enhancing physical and chemical stability of hygroscopic hydroxytyrosol by cocrystal formation
文献类型：期刊论文
| 作者 | Zhu, Bingqing2; Xia, Mengyuan1,2; Ding, Zhenfeng1,2; Rong, Xiaoyi2; Mei, Xuefeng1,2
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2023-11-05 |
| 卷号 | 646页码:8 |
| ISSN号 | 0378-5173 |
| 关键词 | Hydroxytyrosol Cocrystal Solidification Hygroscopicity Stability |
| DOI | 10.1016/j.ijpharm.2023.123470 |
| 通讯作者 | Mei, Xuefeng(xuefengmei@simm.ac.cn) |
| 英文摘要 | Hydroxytyrosol (HT) is a natural phenolic compound with potent antioxidant activity extracted from olive trees. It is generally a slightly hydrated viscous liquid at ambient conditions, and it is highly susceptible to oxygen due to the presence of catechol moiety. Although encapsulation technique provides HT in powder form, it does not improve its chemical stability. Herein, we propose an efficient solution to the high hygroscopicity and poor stability of HT. Four cocrystals were first reported, and their intermolecular interactions were analyzed in detail. After cocrystallization, the melting point is increased and the hygroscopicity is significantly decreased. HT cocrystals are thus solid at room temperature. Moreover, hydroxytyrosol cocrystals with betaine (HT-BET) and nicotinamide (HT-NIC) demonstrate superior chemical stability than pure HT, olive extract, and HT encapsulation material. Therefore, cocrystallization can be considered as a promising approach to overcome the application obstacles of HT. |
| WOS关键词 | PHENOLIC-COMPOUNDS ; METABOLISM ; ABSORPTION |
| 资助项目 | Shanghai Sailing Program[20YF1457400] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001097653000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307739]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Bingqing,Xia, Mengyuan,Ding, Zhenfeng,et al. Enhancing physical and chemical stability of hygroscopic hydroxytyrosol by cocrystal formation[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2023,646:8. |
| APA | Zhu, Bingqing,Xia, Mengyuan,Ding, Zhenfeng,Rong, Xiaoyi,&Mei, Xuefeng.(2023).Enhancing physical and chemical stability of hygroscopic hydroxytyrosol by cocrystal formation.INTERNATIONAL JOURNAL OF PHARMACEUTICS,646,8. |
| MLA | Zhu, Bingqing,et al."Enhancing physical and chemical stability of hygroscopic hydroxytyrosol by cocrystal formation".INTERNATIONAL JOURNAL OF PHARMACEUTICS 646(2023):8. |
入库方式： OAI收割
来源：上海药物研究所
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