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Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities

文献类型：期刊论文

作者Cao, Guangchao3,4; Ning, Ruonan2; Zhao, Jie3,4; Yao, Jiaying1; Chang, Linyue3,4; Mu, Hongyan3,4; Zhang, Rujun4; Chen, Zhenhua4; Gong, Fengbei3,4; He, Shijun1
刊名BIOORGANIC CHEMISTRY
出版日期2023-12-01
卷号141页码:19
ISSN号0045-2068
关键词Tripterygium wilfordii Dihydro beta -agarofuran sesquiterpenoid Osteoclastgenesis Immunosuppressive
DOI10.1016/j.bioorg.2023.106886
通讯作者He, Shijun(heshijun@shutcm.edu.cn) ; Jiang, Min(jiangm263@163.com) ; Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要Extensive phytochemical investigation of the seeds of Tripterygium wilfordii led to the identification of 54 polyesterified dihydro-beta-agarofuran-type sesquiterpenoids, including 27 previously undescribed ones, named Trip-wilin I-XXVII (1-27). Comprehensive spectroscopic and single-crystal X-ray diffraction analyses, along with electronic circular dichroism (ECD) calculations were used for the structural elucidation of the new compounds. Biological assay revealed that 37 compounds among the isolates exhibited significant inhibition against osteoclastogenesis induced by receptor activator of nuclear factor -KB ligand (RANKL) at 10 mu M. Further investigation indicated that Triptogelin C-3 (54), with the most potent osteoclastogenesis inhibitory activity, regulated the osteoclast marker genes (MMP-9, c-Fos, CTSK, and TRAP) and proteins in a dose-dependent manner in vitro. Besides, celaforin D-1 (28), 1 alpha,6 beta,15-triacetoxy-8 alpha,9 alpha-dibenzoyloxy-2 alpha-hydroxydihydro-beta-agarofuran (34), triptogelin A-2 (37), and chiapen D (49) showed moderate suppressive effects on the proliferation of T and B lymphocytes with IC50 values ranging between 8.1 +/- 0.8 and 19.0 +/- 0.9 mu M.
WOS关键词POLYOL ESTERS ; ALKALOIDS ; AGENTS ; STEMS ; FLAVONOIDS ; ROOTS ; BONE
资助项目fund from Shanghai Key Laboratory of Tuberculosis[2022-KF-07] ; Shanghai Science and Technology Commission Project[21S11901500] ; National Natural Science Foundation of China[22277076]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:001092737800001
源URL[http://119.78.100.183/handle/2S10ELR8/307754]  
专题中国科学院上海药物研究所
通讯作者He, Shijun; Jiang, Min; Zhao, Weimin
作者单位1.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ Sch Med, Ruijin Hosp, Dept Orthopaed,Shanghai Key Lab Prevent & Treatmen, Shanghai Inst Traumatol & Orthopaed,Sch Med, Shanghai 200025, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Guangchao,Ning, Ruonan,Zhao, Jie,et al. Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities[J]. BIOORGANIC CHEMISTRY,2023,141:19.
APA Cao, Guangchao.,Ning, Ruonan.,Zhao, Jie.,Yao, Jiaying.,Chang, Linyue.,...&Zhao, Weimin.(2023).Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities.BIOORGANIC CHEMISTRY,141,19.
MLA Cao, Guangchao,et al."Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities".BIOORGANIC CHEMISTRY 141(2023):19.

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来源：上海药物研究所

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