Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum
文献类型：期刊论文
| 作者 | Qi, Yu1; Wang, Zhongle1; Zhang, Jingwen1; Tang, Shuhua1; Zhu, Haoyun1; Jiang, Bing1; Li, Xinhua1; Wang, Jiabao1; Sun, Zhongmin2; Zhao, Min1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2023-05-03 |
| 页码 | 10 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00087 |
| 通讯作者 | Zhu, Haoru(zhuhaoru@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn) |
| 英文摘要 | Nine new chromane-type meroterpenoids, including the rare nor-meroterpenoid sargasilol A (1) and the eight meroditerpenoids sargasilols B-I (2-9), were isolated from a China Sea collection of the brown alga Sargassum siliquastrum, together with six known analogues (10-15). The structures of the new chromanes were identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1- 3 and 6-15 exhibited inhibition against LPS-induced NO production in BV-2 microglial cells, and 1, with a shorter carbon chain, was the most active one. Compound 1 was established as an anti-neuroinflammatory agent through targeting the IKK/I kappa B/NF-kappa B signaling pathway. As such, the chromanes from brown algae could provide promising anti-neuroinflammatory lead compounds for further structural modification. |
| WOS关键词 | ANTIOXIDANT ACTIVITY ; MOJABANCHROMANOL ; DERIVATIVES ; DITERPENES ; CHROMENE |
| 资助项目 | National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Scientific Center of Wenzhou Medical University |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000984340900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182969]  |
| 专题 | 中国科学院海洋研究所 |
| 通讯作者 | Zhu, Haoru; Yan, Pengcheng |
| 作者单位 | 1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Wang, Zhongle,Zhang, Jingwen,et al. Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum[J]. JOURNAL OF NATURAL PRODUCTS,2023:10. |
| APA | Qi, Yu.,Wang, Zhongle.,Zhang, Jingwen.,Tang, Shuhua.,Zhu, Haoyun.,...&Yan, Pengcheng.(2023).Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum.JOURNAL OF NATURAL PRODUCTS,10. |
| MLA | Qi, Yu,et al."Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum".JOURNAL OF NATURAL PRODUCTS (2023):10. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。