Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway
文献类型：期刊论文
| 作者 | Liu, Shuai1; Gao, Xintao1; Yin, Yulan1; Wang, Jing4 ; Dong, Kehong1; Shi, Dayong2; Wu, Xiaochen1; Guo, Chuanlong1,2,3
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| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
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| 出版日期 | 2023-07-01 |
| 卷号 | 177页码:10 |
| ISSN号 | 0278-6915 |
| 关键词 | Silk fibroin peptide Naringin Acute kidney injury Mitophagy cGAS-STING pathway |
| DOI | 10.1016/j.fct.2023.113844 |
| 通讯作者 | Guo, Chuanlong(guochuanlong@qust.edu.cn) |
| 英文摘要 | Silk fibroin (SF) has excellent biocompatibility and biodegradability as a biomaterial. The purity and molecular weight distribution of silk fibroin peptide (SFP) make it more suitable for medical application. In this study, SFP nanofibers (molecular weight similar to 30kD) were prepared through CaCl2/H2O/C2H5OH solution decomposition and dialysis, and adsorbed naringenin (NGN) to obtain SFP/NGN NFs. In vitro results showed that SFP/NGN NFs increased the antioxidant activity of NGN and protected HK-2 cells from cisplatin-induced damage. In vivo results also showed that SFP/NGN NFs protected mice from cisplatin-induced acute kidney injury (AKI). The mechanism results showed that cisplatin induced mitochondrial damage, as well as increased mitophagy and mtDNA release, which activated the cGAS-STING pathway and induced the expression of inflammatory factors such as IL-6 and TNF-alpha. Interestingly, SFP/NGN NFs further activated mitophagy and inhibited mtDNA release and cGAS-STING pathway. Demonstrated that mitophagy-mtDNA-cGAS-STING signal axis was involved in the kidney protection mechanism of SFP/NGN NFs. In conclusion, our study confirmed that SFP/NGN NFs are candidates for protection of cisplatin-induced AKI, which is worthy of further study. |
| WOS关键词 | INFLAMMATION ; DNA ; MECHANISMS ; MITOPHAGY ; APOPTOSIS ; DISEASES |
| 资助项目 | Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS ; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] ; State Key Laboratory of Microbial Technology Open Projects Fund[M2021-14] ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia[NJYT-18-B29] ; Doctoral Scientific Research Foundation of Inner Mongolia[BTTCRCQD2018001] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:001010725500001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182430]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Guo, Chuanlong |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266273, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuai,Gao, Xintao,Yin, Yulan,et al. Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway[J]. FOOD AND CHEMICAL TOXICOLOGY,2023,177:10. |
| APA | Liu, Shuai.,Gao, Xintao.,Yin, Yulan.,Wang, Jing.,Dong, Kehong.,...&Guo, Chuanlong.(2023).Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.FOOD AND CHEMICAL TOXICOLOGY,177,10. |
| MLA | Liu, Shuai,et al."Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway".FOOD AND CHEMICAL TOXICOLOGY 177(2023):10. |
入库方式： OAI收割
来源：海洋研究所
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