Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts
文献类型：期刊论文
| 作者 | Dong, Yu-Liang1,2,3,5; Li, Xiao-Ming1,2,3,4; Shi, Xiao-Shan2,3 ; Wang, Yi-Ran1,2,3,5; Wang, Bin-Gui1,2,3,4,5; Meng, Ling-Hong1,2,3,4,5
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2023-05-10 |
| 卷号 | 21期号:5页码:10 |
| 关键词 | diketopiperazine Aspergillus versicolor deep-sea coral endophytic fungus antimicrobial activity |
| DOI | 10.3390/md21050293 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Two new quinazolinone diketopiperazine alkaloids, including versicomide E (2) and cottoquinazoline H (4), together with ten known compounds (1, 3, and 5-12) were isolated and identified from Aspergillus versicolor AS-212, an endozoic fungus associated with the deep-sea coral Hemicorallium cf. imperiale, which was collected from the Magellan Seamounts. Their chemical structures were determined by an extensive interpretation of the spectroscopic and X-ray crystallographic data as well as specific rotation calculation, ECD calculation, and comparison of their ECD spectra. The absolute configurations of ()-isoversicomide A (1) and cottoquinazoline A (3) were not assigned in the literature reports and were solved in the present work by single-crystal X-ray diffraction analysis. In the antibacterial assays, compound 3 exhibited antibacterial activity against aquatic pathogenic bacteria Aeromonas hydrophilia with an MIC value of 18.6 mu M, while compounds 4 and 8 exhibited inhibitory effects against Vibrio harveyi and V. parahaemolyticus with MIC values ranging from 9.0 to 18.1 mu M. |
| WOS关键词 | METABOLITES ; ANTIFUNGAL ; STRAIN |
| 资助项目 | National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[41976090] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001033226700001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182726]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
| 作者单位 | 1.Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yu-Liang,Li, Xiao-Ming,Shi, Xiao-Shan,et al. Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts[J]. MARINE DRUGS,2023,21(5):10. |
| APA | Dong, Yu-Liang,Li, Xiao-Ming,Shi, Xiao-Shan,Wang, Yi-Ran,Wang, Bin-Gui,&Meng, Ling-Hong.(2023).Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts.MARINE DRUGS,21(5),10. |
| MLA | Dong, Yu-Liang,et al."Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts".MARINE DRUGS 21.5(2023):10. |
入库方式： OAI收割
来源：海洋研究所
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