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Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)

文献类型：期刊论文

作者Chen, Xiao-Dan1,3,5; Yang, Sui-Qun1,3,4; Li, Xiao-Ming1,3,4; Wang, Bin-Gui1,2,3,4,5; Li, Xin1,2,3,4
刊名DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
出版日期2023-09-01
卷号199页码:7
ISSN号0967-0637
关键词Cold seep Furcasterigmium furcatum Acremonium furcatum Polyketides Ascochlorins Antibacterial activity
DOI10.1016/j.dsr.2023.104114
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn)
英文摘要Three new secondary metabolites, including a new polyketide, acrefurcatone A (1), a new ascochlorin analogue, acremochlorin N (2), and 3-phenylcyclopentane-1,2-diol (& PLUSMN;-3), a pair of new naturally occurring enantiomers, along with nine known ascochlorins (4-12), were identified from Furcasterigmium furcatum CS-280 (syn. Acremonium furcatum CS-280), a fungus isolated from the deep-sea cold-seep sediment samples collected in the South China Sea. Their structures were determined by detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative configurations of compounds 1-3 were assigned by NOESY correlations combined with gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis, while their absolute configurations were assigned by time-dependent density functional (TDDFT) ECD calculations and specific rotation calculations. Compound 1 exhibited potent activity against the human pathogenic bacterium Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) value of 8 & mu;g/mL. The isolated ascochlorins also showed potent activities against aquatic bacteria, especially for Vibrio harveyi and V. alginolyticus, with MIC values comparable to chloramphenicol. Analysis of the structure-activity relationship indicated that the cinnamate derivative, such as compound 1, or the presence of chlorine atom in ascochlorin derivatives, such as compounds 4, 6, and 7, significantly enhanced the antibacterial activities. This is the first report of anti-Vibrio activities for ascochlorin derivatives.
WOS关键词METABOLITES ; INHIBITOR
资助项目National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[KEXUE2020GZ02] ; Senior User Project of RV KEXUE[ZR2021ZD28] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; RV KEXUE of the National Major Science and Technology Infrastructure from Chinese Academy of Sciences ; Oceanographic Data Center at IOCAS ; [82003648]
WOS研究方向Oceanography
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:001055658900001
源URL[http://ir.qdio.ac.cn/handle/337002/182840]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Li, Xin
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
5.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xiao-Dan,Yang, Sui-Qun,Li, Xiao-Ming,et al. Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)[J]. DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,2023,199:7.
APA Chen, Xiao-Dan,Yang, Sui-Qun,Li, Xiao-Ming,Wang, Bin-Gui,&Li, Xin.(2023).Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum).DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS,199,7.
MLA Chen, Xiao-Dan,et al."Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum)".DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS 199(2023):7.

入库方式： OAI收割

来源：海洋研究所

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