Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection
文献类型：期刊论文
| 作者 | Qin, Kunpeng1,2,3; Jiang, Shuai1,2,3; Xu, Hang1,2,3 ; Yuan, Zihao1,3; Sun, Li1,2,3
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| 刊名 | CELL REPORTS
 |
| 出版日期 | 2023-05-30 |
| 卷号 | 42期号:5页码:18 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2023.112414 |
| 通讯作者 | Jiang, Shuai(sjiang@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Gasdermin (GSDM) is a family of proteins that execute pyroptosis in vertebrate. In invertebrate, pyroptotic GSDM was documented only in coral. Recent studies identified abundant GSDM structural homologs in Mol-lusca, but their functions are unclear. Herein, we report a functional GSDM from Pacific abalone Haliotis discus (HdGSDME). HdGSDME is specifically activated by abalone caspase 3 (HdCASP3) cleavage at two distinct sites, generating two active isoforms with pyroptotic and cytotoxic activities. HdGSDME possesses evolution-arily conserved residues that proved to be essential to the N-terminal pore-formation and C-terminal auto -in-hibition capacities. Bacterial challenge activates the HdCASP3-HdGSDME pathway and induces pyroptosis and extracellular traps in abalone. Blockage of the HdCASP3-HdGSDME axis promotes bacterial invasion and host mortality. Collectively, this study reveals the existence of functionally conserved and yet distinct -featured GSDM in Mollusca and provides insights into the function and evolution of invertebrate GSDM. |
| WOS关键词 | CELL-DEATH ; INFLAMMASOME ; CASPASES ; CLEAVAGE ; EVOLUTION ; GENOME ; FAMILY ; OYSTER ; GSDMD |
| 资助项目 | Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203000] ; Youth Innovation Promotion Association CAS[2021204] ; National Key Research and Development Project of China[2018YFD0900500] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000986046500001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182960]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Jiang, Shuai; Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Kunpeng,Jiang, Shuai,Xu, Hang,et al. Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection[J]. CELL REPORTS,2023,42(5):18. |
| APA | Qin, Kunpeng,Jiang, Shuai,Xu, Hang,Yuan, Zihao,&Sun, Li.(2023).Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection.CELL REPORTS,42(5),18. |
| MLA | Qin, Kunpeng,et al."Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection".CELL REPORTS 42.5(2023):18. |
入库方式： OAI收割
来源：海洋研究所
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