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A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury

文献类型：期刊论文

作者Liu, Yang Doris1,6,8,9; He, Jun7; Luan, Weiying1,5,8,9; Xu, Yanfeng7; Li, Qianqian1,3,4,8,9; Pan, Lishan7; Liu, Jianguo1,2,8,9
刊名ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
出版日期2023-05-01
卷号72页码:10
ISSN号2211-9264
关键词Acid phosphatase Haematococcus astaxanthin Autophagy Coronavirus Kidney injury Lysosome
DOI10.1016/j.algal.2023.103107
通讯作者Liu, Jianguo(jgliu@qdio.ac.cn)
英文摘要Astaxanthin was established to conserve kidney function and subcellular structure through anti-oxidation and/or the free radical scavenging system, yet little research linked a new protective effect to autophagy or lysosomes. We pre-fed Wistar rats with natural astaxanthin, beta-carotene, or placebo and induced acute kidney injury using gentamicin, before examining renal tissues and measuring physiological indices. Qualitative evidence from histopathological and subcellular images, along with quantitative evidence showing treatment effects on blood urea nitrogen and serum creatinine (p < 0.01), indicated that esterified Haematococcus astaxanthin surpassed beta-carotene at effectively counteracting chemical damage and protecting the kidneys from injury. Proliferation of enlarged lysosomes and mediation analysis results revealing enhanced lysosomal acid phosphatase activity were consistent with the hypothesized autophagy-lysosomal pathway being up-regulated by astaxanthin intake (p < 0.05). In conclusion, the protective effect of astaxanthin against acute kidney injury exerted through the autophagy-lysosomal detoxification pathway, which totally different from the anti-oxidation and/or conventional SOD-dependent free radical scavenging system, was demonstrated with strong evidence. In light of the pandemic outbreak of novel coronavirus pneumonia associated with a virus preferentially targeting the renal tubular cells, dietary astaxanthin may help bring down incidence rate of coronavirus disease, cases of acute kidney injury secondary to the disease, and mortality rate from acute kidney injury, especially when a standard of care treatment for the infectious disease is pending.
WOS关键词BLOOD MONONUCLEAR-CELLS ; OXIDATIVE STRESS ; IN-VITRO ; INDUCED NEPHROTOXICITY ; PLASMA APPEARANCE ; MERCURIC-CHLORIDE ; BETA-CAROTENE ; LOCALIZATION ; NEPHROPATHY ; CORONAVIRUS
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences, China[XDB42000000] ; TS Industrial Experts Programme[LJNY202102] ; Laboratory for Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology[MS2019N001] ; Chinese Academy of Sciences Biological Resources Service Network Initiative[ZSTH-024]
WOS研究方向Biotechnology & Applied Microbiology
语种英语
出版者ELSEVIER
WOS记录号WOS:000988564100001
源URL[http://ir.qdio.ac.cn/handle/337002/183050]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Liu, Jianguo
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
3.Chinese Acad Sci, South China Bot Garden, Key Lab South China Agr Plant Mol Anal & Genet Imp, Guangzhou 510650, Peoples R China
4.Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Univ British Columbia, Fac Med, Vancouver, BC V6T 1Z3, Canada
7.Inst Lab Anim Sci, Ctr Safety Evaluat & Res Drugs, Beijing 100021, Peoples R China
8.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
9.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao 266071, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yang Doris,He, Jun,Luan, Weiying,et al. A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2023,72:10.
APA Liu, Yang Doris.,He, Jun.,Luan, Weiying.,Xu, Yanfeng.,Li, Qianqian.,...&Liu, Jianguo.(2023).A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,72,10.
MLA Liu, Yang Doris,et al."A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 72(2023):10.

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来源：海洋研究所

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