Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3
文献类型：期刊论文
| 作者 | Zhang, Zhanwei1,2; Guan, Xiaolu1 |
| 刊名 | GENES
 |
| 出版日期 | 2023-04-22 |
| 卷号 | 14期号:5页码:12 |
| 关键词 | MicroRNA Paralichthys olivaceus bacterial infection autophagy immune regulation |
| DOI | 10.3390/genes14050958 |
| 通讯作者 | Guan, Xiaolu(guanxiaolu@qdio.ac.cn) |
| 英文摘要 | MicroRNAs (miRNAs) are small RNA molecules that function in the post-transcriptionally regulation of the expression of diverse genes, including those involved in immune defense. Edwardsiella tarda can infect a broad range of hosts and cause severe disease in aquatic species, including Japanese flounder (Paralichthys olivaceus). In this study, we examined the regulation mechanism of a flounder miRNA, pol-miR-155, during the infection of E. tarda. Pol-miR-155 was identified to target flounder ATG3. Overexpression of pol-miR-155 or knockdown of ATG3 expression suppressed autophagy and promoted the intracellular replication of E. tarda in flounder cells. Overexpression of pol-miR-155 activated the NF-?B signaling pathway and further promoted the expression of downstream immune related genes of interleukin (IL)-6 and IL-8. These results unraveled the regulatory effect of pol-miR-155 in autophagy and in E. tarda infection. |
| WOS关键词 | CONJUGATION SYSTEM ; AUTOPHAGY ; PROTEINS ; MECHANISMS ; MICRORNAS ; MIRNAS |
| 资助项目 | National Key Research and Development Program of China[2018YFD0900505] ; National Natural Science Foundation of China[31730100] ; National Natural Science Foundation of China[ZR2021QC124] ; Shandong Provincial Natural Science Foundation ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000997181500001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183071]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Guan, Xiaolu |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhanwei,Guan, Xiaolu. Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3[J]. GENES,2023,14(5):12. |
| APA | Zhang, Zhanwei,&Guan, Xiaolu.(2023).Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3.GENES,14(5),12. |
| MLA | Zhang, Zhanwei,et al."Japanese Flounder pol-miR-155 Is Involved in Edwardsiella tarda Infection via ATG3".GENES 14.5(2023):12. |
入库方式： OAI收割
来源：海洋研究所
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