A novel teleost microRNA regulates autophagy and NF-KB activation during bacterial infection
文献类型：期刊论文
| 作者 | Zhang, Zhanwei1,4; Guan, Xiaolu4; Sun, Li2,3,4 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 137页码:8 |
| 关键词 | MicroRNA Paralichthys olivaceus Bacterial infection Autophagy Immune regulation |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2023.108778 |
| 通讯作者 | Guan, Xiaolu(guanxiaolu@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | MicroRNAs (miRNAs) are a class of non-coding RNAs with regulatory functions in many cellular processes, including immune defense. In this study, we identified novel-m0089-3p, a novel miRNA with unknown function, in the teleost fish Japanese flounder (Paralichthys olivaceus) and investigated its immune function. Novel-m0089 -3p was found to target the autophagy-associated gene ATG7 and negatively regulate ATG7 expression via interaction with the 3' UTR of ATG7. During the infection of the bacterial pathogen Edwardsiella tarda, novel -m0089-3p expression was induced in flounder, which in turn repressed ATG7 expression. Overexpression of novel-m0089-3p or blocking ATG7 expression inhibited autophagy and promoted the intracellular replication of E. tarda. Novel-m0089-3p overexpression, as well as E. tarda infection, activated NF -KB and stimulated the expression of inflammatory cytokines. Together these results revealed an important role of novel-m0089-3p in response to bacterial infection. |
| WOS关键词 | EDWARDSIELLA-TARDA ; COMPREHENSIVE IDENTIFICATION ; ARCHITECTURE ; INFLAMMATION ; MECHANISM ; PROTEINS ; GROUPER ; MIRNAS |
| 资助项目 | Shandong Provincial Natural Science Foundation[ZR2021QC124] ; Laboratory for Marine Biology and Biotechnology[OF2019NO08] ; Pilot National Laboratory for Marine Science and Technology (Qingdao) ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000993886600001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183122]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Guan, Xiaolu; Sun, Li |
| 作者单位 | 1.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhanwei,Guan, Xiaolu,Sun, Li. A novel teleost microRNA regulates autophagy and NF-KB activation during bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2023,137:8. |
| APA | Zhang, Zhanwei,Guan, Xiaolu,&Sun, Li.(2023).A novel teleost microRNA regulates autophagy and NF-KB activation during bacterial infection.FISH & SHELLFISH IMMUNOLOGY,137,8. |
| MLA | Zhang, Zhanwei,et al."A novel teleost microRNA regulates autophagy and NF-KB activation during bacterial infection".FISH & SHELLFISH IMMUNOLOGY 137(2023):8. |
入库方式： OAI收割
来源：海洋研究所
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