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Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis

文献类型：期刊论文

作者Hu, Xue-Yi1,3,4; Li, Xiao-Ming1,3; Liu, Hui1,3; Wang, Bin-Gui1,2,3,4; Meng, Ling-Hong1,2,3
刊名BIOORGANIC CHEMISTRY
出版日期2022-11-01
卷号128页码:8
关键词Penicillium chermesinum Comparative transcriptome analysis Meroterpenoids Antimicrobial activitie Plausible biosynthesis pathway
ISSN号0045-2068
DOI10.1016/j.bioorg.2022.106021
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要As the development of genetic and bioinformatic, the strategy of "bottom-up", combined with genome and transcriptome techniques, was considered as an efficient and practical method to break through the limitation of traditional discovery of natural products. Generally, comparative transcriptome analysis could be useful to guide the optimization of fungal cultivation conditions in which the transcriptional level of interesting compounds is higher. The transcriptome analysis of the algal endophytic fungus Penicillium chermesinum EN-480 indicated that fermentation of this fungus in modified rice solid medium could produce some metabolites different from those cultivated in other media. Four new meroterpenoids (compounds 1-4, namely, chermesins E-H) were characterized and their structures were determined by HRESIMS and NMR spectra. The absolute configurations were confirmed by NOESY experiments, X-ray diffraction analysis, and comparison of ECD cotton effects. Antimicrobial activities against human- and aqua-bacteria as well as against plant-pathogenic fungi were assayed. The plausible biosynthesis pathway of these compounds was discussed.
WOS关键词NATURAL-PRODUCTS ; FUNGUS ; BIOSYNTHESIS ; REVEALS ; PATHWAY ; GENE
资助项目National Natural Science Foundation of China[42176115] ; Laboratory of Marine Biology and Biotechnology of the Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001000178600001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://ir.qdio.ac.cn/handle/337002/183213]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Meng, Ling-Hong
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao Natl Lab Marine Sci & Technol, Nanhai Rd 7, Qingdao 266071, Peoples R China
4.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,et al. Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis[J]. BIOORGANIC CHEMISTRY,2022,128:8.
APA Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis.BIOORGANIC CHEMISTRY,128,8.
MLA Hu, Xue-Yi,et al."Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis".BIOORGANIC CHEMISTRY 128(2022):8.

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来源：海洋研究所

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