Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130
文献类型：期刊论文
| 作者 | Ying, Zhen1,2; Li, Xiao-Ming1; Wang, Bin-Gui1,2,3 ; Li, Hong-Lei1; Meng, Ling-Hong1,2
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| 刊名 | JOURNAL OF ANTIBIOTICS
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| 出版日期 | 2023-05-31 |
| 页码 | 4 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-023-00634-x |
| 通讯作者 | Li, Hong-Lei(lihonglei@qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | A new steroid with strong antibacterial activity, rubensteroid A (1), along with its decarboxylic analogue, solitumergosterol A (2), were isolated and identified from the Magellan Seamount-derived fungus Penicillium rubens AS-130. The structure and absolute configuration of compound 1 were established by detailed interpretation of NMR spectroscopic analysis, mass spectrometry data, and TDDFT-ECD calculations. Compound 1 had a rare 6/6/6/6/5 pentacyclic system, which might be the [4 + 2] Diels-Alder adduct of 14,15-didehydroergosterol (14-DHE) cycloaddition with maleic acid or maleimide, followed by decarboxylation. Rubensteroid A (1) exhibited potent antibacterial activity against Escherichia coli and Vibrio parahaemolyticus, both with MIC value of 0.5 mu g/mL. |
| 资助项目 | National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Shandong Province[ZR2018BD031] ; China Postdoctoral Science Foundation[2018M632732] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000998234400001 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183216]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Hong-Lei; Meng, Ling-Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ying, Zhen,Li, Xiao-Ming,Wang, Bin-Gui,et al. Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130[J]. JOURNAL OF ANTIBIOTICS,2023:4. |
| APA | Ying, Zhen,Li, Xiao-Ming,Wang, Bin-Gui,Li, Hong-Lei,&Meng, Ling-Hong.(2023).Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130.JOURNAL OF ANTIBIOTICS,4. |
| MLA | Ying, Zhen,et al."Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130".JOURNAL OF ANTIBIOTICS (2023):4. |
入库方式： OAI收割
来源：海洋研究所
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