The Toll pathway and Duox-ROS system are required for the clam antibacterial immune response in the hepatopancreas
文献类型：期刊论文
| 作者 | Yu, Jiajia2,3 ; Teng, Shuangshuang1; Yue, Xin2; Wang, Hongxia2; Liu, Baozhong2
|
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2023-09-15 |
| 卷号 | 574页码:10 |
| ISSN号 | 0044-8486 |
| 关键词 | Meretrix petechialis Vibrio parahaemolyticus Vibrio load Toll pathway ROS system |
| DOI | 10.1016/j.aquaculture.2023.739637 |
| 通讯作者 | Wang, Hongxia(hxwang@qdio.ac.cn) |
| 英文摘要 | Vibriosis is one of the most important bacterial diseases that can cause mass mortality of mollusks, especially in summer, and has contributed to dramatic economic losses. Infection is the result of complex molecular interactions between the host and invading agents. Understanding the interaction mechanism could provide a scientific basis for disease control and genetic breeding of resistant varieties. In this paper, the clam Meretrix petechialis was challenged with Vibrio parahaemolyticus to simulate bacterial infection in the natural environment. The Vibrio load variation in the clam hepatopancreas was surveyed during the early phase of Vibrio infection (i.e., latency, prodrome), and the results showed that the Vibrio load was high at 1 dpi (days post-infection), and then dramatically decreased at 2 dpi and remained low at the following time points. The key genes in Toll pathway and the reactive oxygen species (ROS) system were activated to release antibacterial peptide (AMP) and H2O2 during early bacterial infection, respectively. An RNAi experiment further supported that the Toll pathway and ROS system could directly control Vibrio abundance by producing AMP and H2O2. This study provides novel insights into the identity of host factors that enhance or restrict pathogenesis. |
| WOS关键词 | IN-SITU HYBRIDIZATION ; MOLECULAR CHARACTERIZATION ; INNATE IMMUNITY ; MANILA CLAM ; RUDITAPES-PHILIPPINARUM ; MERETRIX-PETECHIALIS ; BACTERIAL-INFECTION ; RIBOSOMAL-RNA ; DROSOPHILA ; HOMEOSTASIS |
| 资助项目 | Strategic Priority Research Pro-gram of the Chinese Academy of Sciences[XDA24030304] ; Key Research and Development Program of Shandong[ZR2020MD089] ; Natural Science Foundation of Shandong Province[CARS-49] ; Taishan Industrial Leading Talents Project to Shandong Dehe Mingxing Biotechnology Co., Ltd. ; [2021LZGC029] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001001344100001 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/183247]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Hongxia |
| 作者单位 | 1.Zhejiang Mariculture Res Inst, Zhejiang Key Lab Exploitat, Preservat Coastal Bioresource Wenzhou Key Lab Mari, Wenzhou 325005, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jiajia,Teng, Shuangshuang,Yue, Xin,et al. The Toll pathway and Duox-ROS system are required for the clam antibacterial immune response in the hepatopancreas[J]. AQUACULTURE,2023,574:10. |
| APA | Yu, Jiajia,Teng, Shuangshuang,Yue, Xin,Wang, Hongxia,&Liu, Baozhong.(2023).The Toll pathway and Duox-ROS system are required for the clam antibacterial immune response in the hepatopancreas.AQUACULTURE,574,10. |
| MLA | Yu, Jiajia,et al."The Toll pathway and Duox-ROS system are required for the clam antibacterial immune response in the hepatopancreas".AQUACULTURE 574(2023):10. |
入库方式： OAI收割
来源：海洋研究所
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