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Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers

文献类型：期刊论文

作者Xing, Lili1,2,5; Wang, Lingyu3; Liu, Shilin1,2,5; Sun, Lina1,2,5; Wessel, Gary M.4; Yang, Hongsheng1,2,5
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2023-08-01
卷号24期号:15页码:18
ISSN号1661-6596
关键词single-cell RNA-seq pigmentation sea cucumber melanin quinone pigments nutritional and medicinal value
DOI10.3390/ijms241512213
通讯作者Sun, Lina(sunlina@qdio.ac.cn) ; Wessel, Gary M.(rhet@brown.edu)
英文摘要The sea cucumber Apostichopus japonicus has important nutritional and medicinal value. Unfortunately, we know little of the source of active chemicals in this animal, but the plentiful pigments of these animals are thought to function in intriguing ways for translation into clinical and food chemistry usage. Here, we found key cell groups with the gene activity predicted for the color morphology of sea cucumber body using single-cell RNA-seq. We refer to these cell populations as melanocytes and quinocytes, which are responsible for the synthesis of melanin and quinone pigments, respectively. We integrated analysis of pigment biochemistry with the transcript profiles to illuminate the molecular mechanisms regulating distinct pigment formation in echinoderms. In concert with the correlated pigment analysis from each color morph, this study expands our understanding of medically important pigment production, as well as the genetic mechanisms for color morphs, and provides deep datasets for exploring advancements in the fields of bioactives and nutraceuticals.
WOS关键词NEURAL CREST ; MELANIN ; EVOLUTION ; STEM ; SPECIFICATION ; CHIMAPHILIN ; DECREASES ; INDUCTION ; ZEBRAFISH ; QUINONES
资助项目National Natural Science Foundation of China[42106109] ; Natural Science Foundation of Shandong Province Youth Program[ZR2020QD100] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030304] ; Agricultural Seed Project of Shandong Province[2020LZGC015] ; National Institutes of Health USA[1R35GM140897]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:001046297000001
源URL[http://ir.qdio.ac.cn/handle/337002/182741]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Sun, Lina; Wessel, Gary M.
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Duke Univ, Dept Biol, Durham, NC 27708 USA
4.Brown Univ, Dept Mol Biol Cellular Biol & Biochem, Providence, RI 02912 USA
5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Xing, Lili,Wang, Lingyu,Liu, Shilin,et al. Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(15):18.
APA Xing, Lili,Wang, Lingyu,Liu, Shilin,Sun, Lina,Wessel, Gary M.,&Yang, Hongsheng.(2023).Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(15),18.
MLA Xing, Lili,et al."Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.15(2023):18.

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来源：海洋研究所

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