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DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR

文献类型：期刊论文

作者Wu, Tianzhen2,3; Lei, Yanli2,3,4; Jian, Zhimin1
刊名FRONTIERS IN MARINE SCIENCE
出版日期2023-05-02
卷号10页码:9
关键词stony coral ancestors ultraviolet radiation DNA damage repair positive selection mass extinction calcareous skeleton organisms
DOI10.3389/fmars.2023.1170565
通讯作者Lei, Yanli(leiyanli@qdio.ac.cn) ; Jian, Zhimin(jian@tongji.edu.cn)
英文摘要DNA damage response (DDR) is a complicated network to defend against physical or chemical changes in DNA in all animals. Elevated levels of ultraviolet radiation (UVR) caused DNA damage, which was a reason for the mass extinction that occurred at the Devonian/Carboniferous (D/C) boundary approximately 359 million years ago (Ma). However, the molecular adaptation of the stony coral ancestors that strangely survived the D/C boundary mass extinction is not well understood. In the present study, the molecular clock analysis using fourfold degenerate sites of 1,463 homologous genes of different stony coral species (a representative group of marine organisms with calcareous skeletons) suggested that their common ancestors originated 384.24 Ma, i.e., slightly earlier than the D/C transition. We identified 21 rapidly evolving genes (REGs) and 49 positive selection genes (PSGs) that were significantly enriched in diverse pathways, including the mitotic cell cycle process, intracellular protein transport, and DNA synthesis involved in DNA repair. Interestingly, four REGs and 21 PSGs were significantly enriched in DDR pathways, including the mitotic cell cycle process, DNA synthesis involved in DNA repair, and cellular response to DNA damage stimulus pathways. We hypothesize that enriched DDR genes are likely involved in the enhanced ability of ancient stony corals to detect and repair DNA damage. For example, the DNA polymerase epsilon catalytic subunit (POLE) gene, which encodes the DNA polymerase epsilon catalytic subunit A, mediates interaction with the other three catalytic subunits through its nonenzymatic carboxy-terminal domain. POLE may potentially enhance the binding ability to other subunits to strengthen its function because eight positive selection sites were distributed in the C-terminal of POLE and on the surface of the simulated 3D protein model. Therefore, our results demonstrated for the first time that the precise transfer of DNA information may help stony coral ancestors survive in elevated levels of ultraviolet radiation, suggesting that DDR levels may be critical to the environmental adaptation of calcareous skeletal organisms during climate change.
WOS关键词ULTRAVIOLET-RADIATION ; CLIMATE-CHANGE ; DAMAGE ; DIVERGENCE ; REPLICATION ; SUPEROXIDE ; STRESS ; REEFS
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:000987163200001
出版者FRONTIERS MEDIA SA
源URL[http://ir.qdio.ac.cn/handle/337002/183011]  
专题海洋研究所_海洋生物分类与系统演化实验室
通讯作者Lei, Yanli; Jian, Zhimin
作者单位1.Tongji Univ, State Key Lab Marine Geol, Shanghai, Peoples R China
2.Inst Oceanol, Chinese Acad Sci, Lab Marine Organism Taxon & Phylogeny, Qingdao Key Lab Marine Biodivers & Conservat, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing, Peoples R China
4.Southern Marine Sci & Engn Guangdong Lab Zhuhai, Zhuhai, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Tianzhen,Lei, Yanli,Jian, Zhimin. DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR[J]. FRONTIERS IN MARINE SCIENCE,2023,10:9.
APA Wu, Tianzhen,Lei, Yanli,&Jian, Zhimin.(2023).DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR.FRONTIERS IN MARINE SCIENCE,10,9.
MLA Wu, Tianzhen,et al."DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR".FRONTIERS IN MARINE SCIENCE 10(2023):9.

入库方式： OAI收割

来源：海洋研究所

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