DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection
文献类型：期刊论文
| 作者 | Zhu, Yu-Yue1,2,5; Jiang, Tian-Tong2; Gao, Ge1,6; Wang, Shi-Liang2,7; Jiang, Xing-Wu1,2,4; Xu, Yi-Tong1; Zhai, Xiao-Fan3; Zhou, Hong6; Zhao, Wei-Wei1 |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2023-10-01 |
| 卷号 | 237页码:6 |
| 关键词 | Organic photoelectrochemical electronics Bioanalysis DNA intercalation Superior gain |
| ISSN号 | 0956-5663 |
| DOI | 10.1016/j.bios.2023.115543 |
| 通讯作者 | Zhai, Xiao-Fan(zhaixf@qdio.ac.cn) ; Zhou, Hong(zhouhong@qust.edu.cn) ; Zhao, Wei-Wei(zww@nju.edu.cn) |
| 英文摘要 | DNA intercalation has increasingly been studied for various scenario implementations due to the diverse func-tions of DNA/intercalators. Nascent organic photoelectrochemical transistor (OPECT) biosensing taking place in organic electronics and photoelectrochemical bioanalysis represents a promising technological frontier in the arena. In this work, we first devise DNA intercalation-enabled OPECT for miRNA detection with a superior gain up to 17100. Intercalation of [Ru(bpy)2dppz]2+ within the miRNA-initiated hybrid chain reaction (HCR)-derived duplex DNA is realized for producing anodic photocurrent upon light stimulation, causing the corresponding target-dependent alternation in gate voltage (VG) and hence the modulated channel current (IDS) of poly (3,4-ethylenedioxythiophene) doped with poly (styrene sulfonate) (PEDOT:PSS) under specific drain voltage (VDS) for quantitative miRNA-21 analysis, which shows a wide linear relationship and a low detection limit of 5.5 x 10-15 mol L-1. This study features the DNA intercalation-enabled organic electronics with superior gain and is envisaged to attract more attention to explore DNA adducts for innovative bioelectronics and biosensing, given the diverse DNA binders with multiple functions. |
| WOS关键词 | COMPLEX ; SENSOR |
| 资助项目 | National Natural Science Foundation of China[22174063] ; Basic Scientific Fund for National Public Research Institutes of China[2019Y03] ; Basic Scientific Fund for National Public Research Institutes of China[2020S02] ; Open Fund of Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation[202203] ; Open Fund of Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sus-tainable Development[MRESD-2022-A03] ; Open Fund of Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sustainable Development[MRESD-2022-A03] ; Young Elite Scientists Sponsorship Program by CAST[YESS20210201] |
| WOS研究方向 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001047366300001 |
| 出版者 | ELSEVIER ADVANCED TECHNOLOGY |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/182747]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Zhai, Xiao-Fan; Zhou, Hong; Zhao, Wei-Wei |
| 作者单位 | 1.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China 2.Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Key Lab Marine Ecoenvironm Sci & Technol, 6 Xianxialing Rd, Qingdao 266061, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China 4.Shandong Key Lab Marine Ecol Environm & Disaster P, Qingdao 266061, Peoples R China 5.Guangxi Univ, Coll Chem & Chem Engn, Nanning 530004, Peoples R China 6.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Shandong Key Lab Biochem Anal, Qingdao 266042, Peoples R China 7.Shandong Univ Sci & Technol, Coll Safety & Environm Engn, Qingdao 266590, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yu-Yue,Jiang, Tian-Tong,Gao, Ge,et al. DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection[J]. BIOSENSORS & BIOELECTRONICS,2023,237:6. |
| APA | Zhu, Yu-Yue.,Jiang, Tian-Tong.,Gao, Ge.,Wang, Shi-Liang.,Jiang, Xing-Wu.,...&Zhao, Wei-Wei.(2023).DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection.BIOSENSORS & BIOELECTRONICS,237,6. |
| MLA | Zhu, Yu-Yue,et al."DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection".BIOSENSORS & BIOELECTRONICS 237(2023):6. |
入库方式： OAI收割
来源：海洋研究所
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