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Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity

文献类型：期刊论文

作者Li, Ling3,4; He, Yihao2,4; Wang, Nan4; Li, Yuting1; Du, Yaoyao4; He, Ning3; Wang, Bing2; Zhang, Tong4
刊名MOLECULES
出版日期2023-11-01
卷号28期号:21页码:15
关键词Atractylodes macrocephala rhizoma essential oil atractylone signaling pathway anti-inflammation antioxidative stress intestinal injury reduction
DOI10.3390/molecules28217340
通讯作者Wang, Bing(bwang@simm.ac.cn) ; Zhang, Tong(zhangtong@shutcm.edu.cn)
英文摘要The aim of this study was to conduct a screening of potential therapeutic compounds found in the Atractylodes macrocephala rhizoma essential oil (AO) and explore its mechanism of action in the treatment of ulcerative colitis (UC). An inflammation cell model was employed in conjunction with phospho-antibody array technology to explore potential therapeutic compounds of AO and their anti-inflammatory and antioxidant effects. Furthermore, we assessed their efficacy and mechanisms of action in treating dextran sulfate sodium (DSS)-induced colitis in mice. Via the screening process, we identified atractylone (ATR) as the primary active compound in AO. It has been demonstrated that ATR can both decrease the levels of tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) and increase the expression of adhesion proteins such as claudin, ZO-1, and occludin in vitro. Moreover, ATR has been shown to improve UC symptoms in vivo. Via a non-targeted metabolomics analysis of colon tissue, we identified 57 distinct metabolites that responded to ATR treatment. Subsequent analysis of the metabolic pathways revealed that the action of ATR was primarily focused on the amino acid metabolism pathway. In summary, ATR may alleviate the symptoms of UC by regulating multiple signaling pathways. Additionally, ATR has a comprehensive function in anti-inflammation, antioxidative stress, and intestinal injury reduction.
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; ULCERATIVE-COLITIS ; BARRIER FUNCTION ; INDUCTION ; REMISSION ; KINASE ; OXYGEN ; MICE
资助项目National Key Research and Development Program of China[2022YFC3501705] ; National Natural Science Foundation of China[82274066] ; program of Shanghai Leading Talents[SHLJ2019100] ; Science and Technology Development Fund of Shanghai University of Traditional Chinese Medicine[23KFL046]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001103363700001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/307869]  
专题中国科学院上海药物研究所
通讯作者Wang, Bing; Zhang, Tong
作者单位1.Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Dermatol, Shanghai 200437, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Anhui Univ Chinese Med, Coll Pharm, Hefei 230012, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ling,He, Yihao,Wang, Nan,et al. Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity[J]. MOLECULES,2023,28(21):15.
APA Li, Ling.,He, Yihao.,Wang, Nan.,Li, Yuting.,Du, Yaoyao.,...&Zhang, Tong.(2023).Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity.MOLECULES,28(21),15.
MLA Li, Ling,et al."Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity".MOLECULES 28.21(2023):15.

入库方式： OAI收割

来源：上海药物研究所

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