Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices
文献类型：期刊论文
| 作者 | Li, Deling11,12,13; Shi, Hui8,9,10,11,12; Qi, Qingrong7,11,12; Chang, Baisong6,11,12; Jiang, Yuanwen5; Qian, Kun10; Guan, Xiudong13; Kang, Peng13; Ma, Ning4; Zhang, Yuan13 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2023-11-09 |
| 页码 | 13 |
| 关键词 | aggregates in vivo imaging medical devices NIR-II fluorescence |
| DOI | 10.1002/advs.202303491 |
| 通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Jia, Wang(jiawang@bjtth.org) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Medical devices are commonly implanted underneath the skin, but how to real-time noninvasively monitor their migration, integrity, and biodegradation in human body is still a formidable challenge. Here, the study demonstrates that benzyl violet 4B (BV-4B), a main component in the FDA-approved surgical suture, is found to produce fluorescence signal in the first near-infrared window (NIR-I, 700-900 nm) in polar solutions, whereas BV-4B self-assembles into highly crystalline aggregates upon a formation of ultrasmall nanodots and can emit strong fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) with a dramatic bathochromic shift in the absorption spectrum of approximate to 200 nm. Intriguingly, BV-4B-involved suture knots underneath the skin can be facilely monitored during the whole degradation process in vivo, and the rupture of the customized BV-4B-coated silicone catheter is noninvasively diagnosed by NIR-II imaging. Furthermore, BV-4B suspended in embolization glue achieves hybrid fluorescence-guided surgery (hybrid FGS) for arteriovenous malformation. As a proof-of-concept study, the solid-state BV-4B is successfully used for NIR-II imaging of surgical sutures in operations of patients. Overall, as a clinically translatable solid-state dye, BV-4B can be applied for in vivo monitoring the fate of medical devices by NIR-II imaging. Benzyl Violet 4B (BV-4B), serving as a component in the FDA-approved surgical sutures, is first discovered as a novel solid-state dye in the NIR-II window (1000-1700 nm). It can be used to non-invasively monitor the degradation process of surgical sutures, to diagnose the rupture of BV-4B-coated silicone catheter and to guide the hybrid fluorescence-guided surgery (hybrid FGS) of arteriovenous malformation (AVM) with embolization glue.image |
| WOS关键词 | EMBOLIZATION |
| 资助项目 | Part of this work was performed at the Stanford Nano Shared Facilities (SNSF), supported by the National Science Foundation under award ECCS-1542152. The authors appreciated Qiang Liu for measuring the absolute quantum yield of BV-4B powder, as well as HOR[ECCS-1542152] ; National Science Foundation ; HORIBA application specialist Ren Wanqing[81971668] ; HORIBA application specialist Ren Wanqing[82222034] ; HORIBA application specialist Ren Wanqing[U2267221] ; HORIBA application specialist Ren Wanqing[62027901] ; HORIBA application specialist Ren Wanqing[81930053] ; HORIBA application specialist Ren Wanqing[92059207] ; HORIBA application specialist Ren Wanqing[81227901] ; National Natural Science Foundation of China (NSFC)[2017YFA0205200] ; National Key Research and Development Program of China[TM202301H003] ; Shanghai Municipal Science and Technology Major Project[xx2017017] ; Beijing Nova Program[JCTD-2021-08] ; Beijing Talents Foundation, CAS Youth Interdisciplinary Team[JQ19027] ; Beijing Natural Science Foundation[HLHPTP201703] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[YSP201902] ; Clinical Scientist Supporting grant of Beijing Tiantan Hospital ; Radiology Department at Stanford University[201906080019] ; China Scholarship Council |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:001099155600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/307872]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tian, Jie; Hu, Zhenhua; Jia, Wang; Cheng, Zhen |
| 作者单位 | 1.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 3.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, Intervent Neuroradiol Ctr, Beijing 100070, Peoples R China 5.Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA 6.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 7.Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China 8.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang 110000, Peoples R China 9.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 10.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Deling,Shi, Hui,Qi, Qingrong,et al. Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices[J]. ADVANCED SCIENCE,2023:13. |
| APA | Li, Deling.,Shi, Hui.,Qi, Qingrong.,Chang, Baisong.,Jiang, Yuanwen.,...&Cheng, Zhen.(2023).Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices.ADVANCED SCIENCE,13. |
| MLA | Li, Deling,et al."Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices".ADVANCED SCIENCE (2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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