Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure
文献类型:期刊论文
作者 | Zhang, Guangbo6,7; Yang, Guochun5; Zhou, Yanzhao7; Cao, Zhengtao4; Yin, Ming3; Ma, Lin3; Fan, Ming2,6,7; Zhao, Yong-Qi1,7; Zhu, Lingling1,2,7 |
刊名 | PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY |
出版日期 | 2023-11-23 |
页码 | 14 |
通讯作者邮箱 | yqzhaoprc@sina.com (yong-qi zhao) ; linglingzhuamms@126.com (lingling zhu) |
ISSN号 | 0031-6768 |
关键词 | Intermittent hypoxia Cognitive function Magnetic resonance imaging Cerebral blood flow Acute mountain sickness |
DOI | 10.1007/s00424-023-02885-x |
产权排序 | 3 |
文献子类 | 综述 |
英文摘要 | Intermittent hypoxia training (IHT) is a promising approach that has been used to induce acclimatization to hypoxia and subsequently lower the risk of developing acute mountain sickness (AMS). However, the effects of IHT on cognitive and cerebrovascular function after acute hypoxia exposure have not been characterized. In the present study, we first confirmed that the simplified IHT paradigm was effective at relieving AMS at 4300 m. Second, we found that IHT improved participants' cognitive and neural alterations when they were exposed to hypoxia. Specifically, impaired working memory performance, decreased conflict control function, impaired cognitive control, and aggravated mental fatigue induced by acute hypoxia exposure were significantly alleviated in the IHT group. Furthermore, a reversal of brain swelling induced by acute hypoxia exposure was visualized in the IHT group using magnetic resonance imaging. An increase in cerebral blood flow (CBF) was observed in multiple brain regions of the IHT group after hypoxia exposure as compared with the control group. Based on these findings, the simplified IHT paradigm might facilitate hypoxia acclimatization, alleviate AMS symptoms, and increase CBF in multiple brain regions, thus ameliorating brain swelling and cognitive dysfunction. |
收录类别 | SCI |
WOS关键词 | ACUTE MOUNTAIN-SICKNESS ; HIGH-ALTITUDE ; HIPPOCAMPAL NEUROGENESIS ; BRAIN ; CONFLICT ; MEMORY ; MECHANISMS |
资助项目 | Beijing Science and Technology Commission[Z161100000216134] ; Beijing Science and Technology Commission[7204283] ; Key Program of National Nature Sciences Foundation of China[81430044] |
WOS研究方向 | Physiology |
语种 | 英语 |
出版者 | SPRINGER HEIDELBERG |
WOS记录号 | WOS:001107252300001 |
资助机构 | Beijing Science and Technology Commission ; Key Program of National Nature Sciences Foundation of China |
源URL | [http://ir.psych.ac.cn/handle/311026/46513] |
专题 | 中国科学院心理研究所 |
通讯作者 | Zhao, Yong-Qi; Zhu, Lingling |
作者单位 | 1.Anhui Med Univ, Hefei, Peoples R China 2.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China 3.Peoples Liberat Army Gen Hosp, Med Ctr Chinese 1, Beijing, Peoples R China 4.PLA, AF Med Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 6.Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China 7.Beijing Inst Basic Med Sci, Dept Cognit Sci & Stress Med, 27 Taiping Rd, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Guangbo,Yang, Guochun,Zhou, Yanzhao,et al. Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,2023:14. |
APA | Zhang, Guangbo.,Yang, Guochun.,Zhou, Yanzhao.,Cao, Zhengtao.,Yin, Ming.,...&Zhu, Lingling.(2023).Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure.PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,14. |
MLA | Zhang, Guangbo,et al."Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure".PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023):14. |
入库方式: OAI收割
来源:心理研究所
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