Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness
文献类型：期刊论文
| 作者 | Zhang, Haoran8,9; Zhuang, Yutong6; Dang, Yuanyuan7; Ge, Qianqian10; Yang, Yi10; Xu, Long10; Xia, Xiaoyu5; Laureys, Steven2,3,4; Yu, Shan8,9 ; Zhang, Wangming1,11
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| 刊名 | BRAIN STIMULATION
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| 出版日期 | 2023-09-01 |
| 卷号 | 16期号:5页码:1522-1532 |
| 关键词 | Disorders of consciousness (DoC) Deep brain stimulation (DBS) Centromedian-parafascicular complex (CM-pf) Multiunit activity (MUA) Central thalamus (CT) |
| ISSN号 | 1935-861X |
| DOI | 10.1016/j.brs.2023.09.021 |
| 通讯作者 | Yu, Shan(shan.yu@nlpr.ia.ac.cn) ; Zhang, Wangming(wzhang@vip.126.com) |
| 英文摘要 | Background: Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, the lack of understanding of its electrophysiological characteristics limits the improvement of therapeutic effect. Objective: To investigate the CM-pf electrophysiological characteristics underlying disorders of consciousness (DoC) and its recovery. Methods: We collected the CM-pf electrophysiological signals from 23 DoC patients who underwent central thalamus DBS (CT-DBS) surgery. Five typical electrophysiological features were extracted, including neuronal firing properties, multiunit activity (MUA) properties, signal stability, spike-MUA synchronization strength (syncMUA), and the background noise level. Their correlations with the consciousness level, the outcome, and the primary clinical factors of DoC were analyzed. Results: 11 out of 23 patients (0/2 chronic coma, 5/13 unresponsive wakefulness syndrome/vegetative state (UWS/VS), 6/8 minimally conscious state minus (MCS-)) exhibited an improvement in the level of consciousness after CT-DBS. In CM-pf, significantly stronger gamma band syncMUA strength and alpha band normalized MUA power were found in MCS- patients. In addition, higher firing rates, stronger high-gamma band MUA power and alpha band normalized power, and more stable theta oscillation were correlated with better outcomes. Besides, we also identified electrophysiological properties that are correlated with clinical factors, including etiologies, age, and duration of DoC. Conclusion: We provide comprehensive analyses of the electrophysiological characteristics of CM-pf in DoC patients. Our results support the 'mesocircuit' hypothesis, one proposed mechanism of DoC recovery, and reveal CM-pf electrophysiological features that are crucial for understanding the pathogenesis of DoC, predicting its recovery, and explaining the effect of clinical factors on DoC. |
| WOS关键词 | DEEP BRAIN-STIMULATION ; ANTERIOR FOREBRAIN MESOCIRCUIT ; ALPHA-RHYTHM ; VEGETATIVE STATE ; THALAMIC-STIMULATION ; SUBTHALAMIC NUCLEUS ; AROUSAL REGULATION ; NEURONAL-ACTIVITY ; MULTIUNIT ; RECOVERY |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001092799600001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.ia.ac.cn/handle/173211/54400]  |
| 专题 | 脑图谱与类脑智能实验室 脑机接口与融合智能 |
| 通讯作者 | Yu, Shan; Zhang, Wangming |
| 作者单位 | 1.Southern Med Univ, Zhujiang Hosp, Neurosurg Inst Guangdong Prov,Guangdong Prov Key L, Neurosurg Ctr,Natl Key Clin Specialty,Engn Technol, Guangzhou 510282, Peoples R China 2.Hangzhou Normal Univ, Int Consciousness Sci Inst, Hangzhou, Zhejiang, Peoples R China 3.Liege Univ Hosp, GIGA Consciousness Res Unit, Coma Sci Grp, Liege, Belgium 4.Laval Univ, CERVO Brain Res Ctr, Quebec City, PQ, Canada 5.Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Neurosurg, Beijing 100700, Peoples R China 6.Southern Med Univ, Sch Clin Med 2, Dept Neurosurg, Guangzhou, Peoples R China 7.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing 100853, Peoples R China 8.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China 9.Chinese Acad Sci, Inst Automat, Lab Brain Atlas & Brain inspired Intelligence, Beijing 100190, Peoples R China 10.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Haoran,Zhuang, Yutong,Dang, Yuanyuan,et al. Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness[J]. BRAIN STIMULATION,2023,16(5):1522-1532. |
| APA | Zhang, Haoran.,Zhuang, Yutong.,Dang, Yuanyuan.,Ge, Qianqian.,Yang, Yi.,...&Zhang, Wangming.(2023).Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness.BRAIN STIMULATION,16(5),1522-1532. |
| MLA | Zhang, Haoran,et al."Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness".BRAIN STIMULATION 16.5(2023):1522-1532. |
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来源：自动化研究所
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