Breathing in danger: Unveiling the link between human exposure to outdoor PM2.5 -bound polycyclic aromatic hydrocarbons and lung cancer risk in an urban residential area of China
文献类型：期刊论文
| 作者 | Famiyeh, Lord2,3; Xu, Honghui4; Chen, Ke3; Tang, Yu-Ting5; Ji, Dongsheng6; Xiao, Hang7; Tong, Lei7; Jia, Chunrong8; Guo, Qingjun2,3; He, Jun1,3 |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2024-01-10 |
| 卷号 | 907页码:11 |
| ISSN号 | 0048-9697 |
| 关键词 | Human exposure Breathing PAHs Lung cancer Urban Residential area |
| DOI | 10.1016/j.scitotenv.2023.167762 |
| 通讯作者 | Guo, Qingjun(guoqj@igsnrr.ac.cn) ; He, Jun(Jun.He@nottingham.edu.cn) |
| 英文摘要 | Numerous studies have extensively examined the risk of lung cancer associated with polycyclic aromatic hy-drocarbons (PAHs), with particular emphasis on the 16 priority PAHs. However, this may underestimate the actual risk. This study seeks to enhance the current risk assessment framework by integrating four additional parent PAHs such as Dibenzo[a,h]pyrene, Dibenzo[a,l]pyrene, Dibenzo[a,e]pyrene, 7H-benzo[c]fluorene with potentially high risk of causing cancer. By considering their physicochemical properties, metabolism, and bioavailability, the study also examines the relationship between low molecular weight (LMW) -and high mo-lecular weight (HMW)-PAH doses and the risk of developing cancer in the human lungs. The study was con-ducted in Ningbo, China and identified five PAH sources: natural gas combustion (NGC), vehicular exhaust (VE), coal combustion (CC), biomass burning (BB), and volatilization of unburnt fuel (VUF). This study emphasizes the elevated risk associated with highly carcinogenic PAHs, as they consistently exceed acceptable limits for lung cancer risk throughout the year. Based on the study's estimation, approximately 324 out of every one million individuals exposed to PAHs face an increased cancer risk over their lifetime. This research emphasizes the importance of identifying source specific lung cancer risk in residential areas to protect the exposed population. Moreover, while there is a moderate connection between LMW-PAH doses and lung cancer risk, a strong rela-tionship is observed with HMW-PAHs. |
| WOS关键词 | SOURCE APPORTIONMENT ; PAHS ; DIBENZOPYRENES ; IDENTIFICATION ; DISTRIBUTIONS ; METABOLISM ; DEPOSITION ; SHANGHAI ; SAMPLES |
| 资助项目 | Ningbo Science and Technology Innovation[2022Z028] ; Ningbo Natural Science Foundation Key Project[2023J024] ; Ningbo Commonwealth Programme Key Project[2023S038] ; National Natural Science Foundation of China[41975831] ; National Natural Science Foundation of China[41761144066] ; National Natural Science Foundation of China[41625006] ; National Natural Science Foundation of China[41561144005] ; National Key Research and Development Program of China[2017YFC0212703] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001111687600001 |
| 资助机构 | Ningbo Science and Technology Innovation ; Ningbo Natural Science Foundation Key Project ; Ningbo Commonwealth Programme Key Project ; National Natural Science Foundation of China ; National Key Research and Development Program of China |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/200300]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Guo, Qingjun; He, Jun |
| 作者单位 | 1.Nottingham Ningbo China Beacon Excellence Res & In, Ningbo 315100, Peoples R China 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Ctr Environm Remediat, Beijing 100101, Peoples R China 3.Univ Nottingham Ningbo China, Dept Chem & Environm Engn, 199 Taikang E Rd, Ningbo 315100, Peoples R China 4.Zhejiang Inst Meteorol Sci, Hangzhou 310017, Peoples R China 5.Univ Nottingham Ningbo China, Sch Geog Sci, 199 Taikang E Rd, Ningbo 315100, Peoples R China 6.Chinese Acad Sci, Inst Atmospher Phys, State Kay Lab Atmospher Boundary Layer Phys & Atmo, Beijing 100029, Peoples R China 7.Ningbo Beilun Zhongke Haixi Ind Technol Innovat Ct, Ningbo 318825, Peoples R China 8.Univ Memphis, Sch Publ Hlth, Memphis, TN 38125 USA |
| 推荐引用方式 GB/T 7714 | Famiyeh, Lord,Xu, Honghui,Chen, Ke,et al. Breathing in danger: Unveiling the link between human exposure to outdoor PM2.5 -bound polycyclic aromatic hydrocarbons and lung cancer risk in an urban residential area of China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,907:11. |
| APA | Famiyeh, Lord.,Xu, Honghui.,Chen, Ke.,Tang, Yu-Ting.,Ji, Dongsheng.,...&He, Jun.(2024).Breathing in danger: Unveiling the link between human exposure to outdoor PM2.5 -bound polycyclic aromatic hydrocarbons and lung cancer risk in an urban residential area of China.SCIENCE OF THE TOTAL ENVIRONMENT,907,11. |
| MLA | Famiyeh, Lord,et al."Breathing in danger: Unveiling the link between human exposure to outdoor PM2.5 -bound polycyclic aromatic hydrocarbons and lung cancer risk in an urban residential area of China".SCIENCE OF THE TOTAL ENVIRONMENT 907(2024):11. |
入库方式： OAI收割
来源：地理科学与资源研究所
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