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Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity

文献类型：期刊论文

作者Deng, Zheng4; Liu, Jiawei5; Xi, Min1,2,3; Wang, Chunjie4; Fang, Huapan4; Wu, Xirui1,2,3; Zhang, Cai1,2,3; Sun, Guanting1,2,3; Zhang, Yifan1,2,3; Shen, Lin
刊名NANO TODAY
出版日期2022-12-01
卷号47页码:10
ISSN号1748-0132
关键词Radiotherapy Platinum nanoparticles Shewanella oneidensis MR-1 Immune checkpoint blockade Anti-tumor immunity
DOI10.1016/j.nantod.2022.101656
英文摘要Being widely utilized in clinic to treat solid tumors, the efficacy of radiotherapy (RT) is usually restricted by insufficient deposition of radiation energy and hypoxia-associated tumor radio-resistance. Moreover, as a local treatment technique, RT is ineffective against tumor metastases, the main cause of cancer death. Herein, biogenic platinum nanoparticles (Pt NPs) are in situ synthesized on the surface of Shewanella oneidensis MR-1 (S. oneidensis MR-1), followed by sonication to acquire Pt NPs decorated membrane fragments (PtMFs) for reinforcing the treatment outcome of RT. Thanks to the high-Z element intrinsic property and the catalytic property of Pt NPs in decomposing tumor endogenous H2O2 to produce oxygen, PtMFs not only effectively amplify radiation-induced DNA damages, but also significantly enhance tumor oxygenation to overcome the hypoxia-induced radio-resistance and reprogram the immunosuppressive tumor microenvironment, thereby enhancing antitumor efficacy in vivo. After PtMFs-mediated RT to trigger the immunogenic cell death (ICD), the generated tumor antigens subsequently elicit potent anti-tumor immune responses in the presence of bacterial membrane fragments as natural immunologic adjuvants. Via combination with programmed death-ligand 1 (PD-L1) checkpoint blockade, strong abscopal effects are achieved to effectively inhibit tumor metastases, whereas a long-term immune memory effect to reject rechallenged tumors is further observed. Therefore, such biogenic Pt-based therapeutic platforms present a unique approach for enhanced RT to inhibit tumor metastasis and recurrence by triggering strong anti-tumor immunity. (c) 2022 Elsevier Ltd. All rights reserved.
WOS关键词OXYGEN ; IMMUNOTHERAPY ; THERAPY ; LIGHT
资助项目National Natural Science Foundation of China[52002330] ; National Natural Science Foundation of China[52032008] ; China Postdoctoral Science Foundation[2021M692357] ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; "111" program from the Ministry of Education of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:001070229500001
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; "111" program from the Ministry of Education of China ; "111" program from the Ministry of Education of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; "111" program from the Ministry of Education of China ; "111" program from the Ministry of Education of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; "111" program from the Ministry of Education of China ; "111" program from the Ministry of Education of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; Collaborative Innovation Center of Suzhou Nano Science and Technology ; "111" program from the Ministry of Education of China ; "111" program from the Ministry of Education of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
源URL[http://ir.iggcas.ac.cn/handle/132A11/110854]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Ji, Jiansong; Liu, Zhuang; Yang, Guangbao
作者单位1.Wenzhou Med Univ, Affiliated Hosp 5, Imaging Diag & Intervent Minimally Invas Inst, Key Lab Imaging Diag & Minimally Invas Intervent, Lishui 323000, Peoples R China
2.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiol & Interdisciplinary Sci RADX, Suzhou 215123, Jiangsu, Peoples R China
3.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, State Key Lab Radiat Med & Protect, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China
4.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China
5.Chinese Acad Sci, Innovat Acad Earth Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714		 Deng, Zheng,Liu, Jiawei,Xi, Min,et al. Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity[J]. NANO TODAY,2022,47:10.
APA Deng, Zheng.,Liu, Jiawei.,Xi, Min.,Wang, Chunjie.,Fang, Huapan.,...&Yang, Guangbao.(2022).Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity.NANO TODAY,47,10.
MLA Deng, Zheng,et al."Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity".NANO TODAY 47(2022):10.

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来源：地质与地球物理研究所

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