Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy
文献类型：期刊论文
| 作者 | Wang, Dongdong1,2; Liu, Jiawei1,3; Wang, Changlai2; Zhang, Weiyun4; Yang, Guangbao1; Chen, Yun1; Zhang, Xiaodong1; Wu, Yinglong1; Gu, Long1; Chen, Hongzhong1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2023-05-23 |
| 卷号 | 14期号:1页码:16 |
| DOI | 10.1038/s41467-023-38796-9 |
| 英文摘要 | Cancer immunotherapy is revolutionizing oncology. The marriage of nanotechnology and immunotherapy offers a great opportunity to amplify antitumor immune response in a safe and effective manner. Here, electrochemically active Shewanella oneidensis MR-1 can be applied to produce FDA-approved Prussian blue nanoparticles on a large-scale. We present a mitochondria-targeting nanoplatform, MiBaMc, which consists of Prussian blue decorated bacteria membrane fragments having further modifications with chlorin e6 and triphenylphosphine. We find that MiBaMc specifically targets mitochondria and induces amplified photo-damages and immunogenic cell death of tumor cells under light irradiation. The released tumor antigens subsequently promote the maturation of dendritic cells in tumor-draining lymph nodes, eliciting T cell-mediated immune response. In two tumor-bearing mouse models using female mice, MiBaMc triggered phototherapy synergizes with anti-PDL1 blocking antibody for enhanced tumor inhibition. Collectively, the present study demonstrates biological precipitation synthetic strategy of targeted nanoparticles holds great potential for the preparation of microbial membrane-based nanoplatforms to boost antitumor immunity. Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade. |
| WOS关键词 | IRON ; REDUCTION ; MANGANESE ; BACTERIA ; FE(III) |
| 资助项目 | Singapore National Research Foundation under its Investigatorship[NRF-NRFI2018-03] ; Competitive Research Program[NRF-CRP26-2021-0002] ; Fundamental Research Funds for the Central Universities[YD9990002021] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001001481100018 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | Singapore National Research Foundation under its Investigatorship ; Singapore National Research Foundation under its Investigatorship ; Competitive Research Program ; Competitive Research Program ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Singapore National Research Foundation under its Investigatorship ; Singapore National Research Foundation under its Investigatorship ; Competitive Research Program ; Competitive Research Program ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Singapore National Research Foundation under its Investigatorship ; Singapore National Research Foundation under its Investigatorship ; Competitive Research Program ; Competitive Research Program ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Singapore National Research Foundation under its Investigatorship ; Singapore National Research Foundation under its Investigatorship ; Competitive Research Program ; Competitive Research Program ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/111191]  |
| 专题 | 地质与地球物理研究所_中国科学院地球与行星物理重点实验室 |
| 通讯作者 | Zhao, Yanli |
| 作者单位 | 1.Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, Singapore 637371, Singapore 2.Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Inst Geol & Geophys, Beijing 100029, Peoples R China 4.Shenzhen Univ, Sch Biomed Engn, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dongdong,Liu, Jiawei,Wang, Changlai,et al. Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy[J]. NATURE COMMUNICATIONS,2023,14(1):16. |
| APA | Wang, Dongdong.,Liu, Jiawei.,Wang, Changlai.,Zhang, Weiyun.,Yang, Guangbao.,...&Zhao, Yanli.(2023).Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy.NATURE COMMUNICATIONS,14(1),16. |
| MLA | Wang, Dongdong,et al."Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy".NATURE COMMUNICATIONS 14.1(2023):16. |
入库方式： OAI收割
来源：地质与地球物理研究所
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