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Distinctive calcium isotopic composition of mice organs and fluids: implications for biological research

文献类型：期刊论文

作者Cui, Meng-Meng4,5; Moynier, Frederic4; Su, Ben-Xun3,5; Dai, Wei4; Mahan, Brandon2; Le Borgne, Marie1,6
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
出版日期2023-09-27
页码12
关键词Calcium isotopes Isotope fractionation Body compartments Sex Genetic background
ISSN号1618-2642
DOI10.1007/s00216-023-04962-7
英文摘要The stable calcium (Ca) isotopes offer a minimally invasive method for assessing Ca balance in the body, providing a new avenue for research and clinical applications. In this study, we measured the Ca isotopic composition of soft tissues (brain, muscle, liver, and kidney), mineralized tissue (bone), and blood (plasma) from 10 mice (5 females and 5 males) with three different genetic backgrounds and same age (3 months old). The results reveal a distinctive Ca isotopic composition in different body compartments of mice, primally controlled by each compartment's unique Ca metabolism and genetic background, independent of sex. The bones are enriched in the lighter Ca isotopes (& delta;44/40Cabone = - 0.10 & PLUSMN; 0.55 & PTSTHOUSND;) compared to blood and other soft tissues, reflecting the preferential incorporation of lighter Ca isotopes through bone formation, while heavier Ca isotopes remain preferentially in blood. The brain and muscle are enriched in lighter Ca isotopes (& delta;44/40Cabrain = - 0.10 & PLUSMN; 0.53 & PTSTHOUSND;; & delta;44/40Camuscle = 0.19 & PLUSMN; 0.41 & PTSTHOUSND;) relative to blood and other soft tissues, making the brain the isotopically lightest soft tissues of the mouse body. In contrast, the kidney is enriched in heavier isotopes (& delta;44/40Cakidney = 0.86 & PLUSMN; 0.31 & PTSTHOUSND;) reflecting filtration and reabsorption by the kidney. This study provides important insight into the Ca isotopic composition of various body compartments and fluids.
WOS关键词EXTRACELLULAR CALCIUM ; CA ISOTOPES ; BONE ; FRACTIONATION ; ABSORPTION ; DISEASE ; HOMEOSTASIS ; BALANCE ; KIDNEY ; MODEL
资助项目We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France[101059236] ; European Research Council (ERC) ; University of Chinese Academy of Sciences
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001073781800001
出版者SPRINGER HEIDELBERG
资助机构We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; We thank the two anonymous reviewers and the editor for their thorough comments that greatly improved the quality of our manuscript. We thank the DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of th ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; DIMACAV+ (Domaine damp;apos;Interet Majeur, Astrophysique et Condition damp;apos;Apparition de la Vie) of the region Ile de France ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; European Research Council (ERC) ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences
源URL[http://ir.iggcas.ac.cn/handle/132A11/110777]  
专题地质与地球物理研究所_中国科学院矿产资源研究重点实验室
通讯作者Cui, Meng-Meng; Moynier, Frederic
作者单位1.Univ Paris Cite, F-75018 Paris, France
2.James Cook Univ, Earth & Environm Sci, Townsville, Australia
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Paris Cite, Inst Phys Globe Paris, CNRS, 1 Rue Jussieu, F-75005 Paris, France
5.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Mineral Resources, Beijing 100029, Peoples R China
6.Univ Sorbonne Paris Nord, INSERM, F-75018 Paris, France
推荐引用方式
GB/T 7714		 Cui, Meng-Meng,Moynier, Frederic,Su, Ben-Xun,et al. Distinctive calcium isotopic composition of mice organs and fluids: implications for biological research[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2023:12.
APA Cui, Meng-Meng,Moynier, Frederic,Su, Ben-Xun,Dai, Wei,Mahan, Brandon,&Le Borgne, Marie.(2023).Distinctive calcium isotopic composition of mice organs and fluids: implications for biological research.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,12.
MLA Cui, Meng-Meng,et al."Distinctive calcium isotopic composition of mice organs and fluids: implications for biological research".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2023):12.

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