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Stable potassium isotope distribution in mouse organs and red blood cells: implication for biomarker development

文献类型：期刊论文

作者Cui, Meng-Meng1,5,6; Moynier, Frederic6; Su, Ben-Xun1,5; Dai, Wei6; Hu, Yan6; Rigoussen, Dimitri6; Mahan, Brandon2; Le Borgne, Marie3,4
刊名METALLOMICS
出版日期2023-07-10
卷号15期号:7页码:11
ISSN号1756-5901
关键词K isotopes K concentration mouse organs sex genetic background
DOI10.1093/mtomcs/mfad033
英文摘要Potassium (K) is an essential electrolyte for cellular functions in living organisms, and disturbances in K+ homeostasis could lead to various chronic diseases (e.g. hypertension, cardiac disease, diabetes, and bone health). However, little is known about the natural distribution of stable K isotopes in mammals and their application to investigate bodily homeostasis and/or as biomarkers for diseases. Here, we measured K isotopic compositions (& delta;K-41, per mil deviation of K-41/K-39 from the NIST SRM 3141a standard) of brain, liver, kidney, and red blood cells (RBCs) from 10 mice (five females and five males) with three different genetic backgrounds. Our results reveal that different organs and RBCs have distinct K isotopic signatures. Specifically, the RBCs have heavy K isotopes enrichment with & delta;K-41 ranging from 0.67 to 0.08 & PTSTHOUSND;, while the brains show lighter K isotopic compositions with & delta;K-41 ranging from -1.13 to -0.09 & PTSTHOUSND; compared to the livers (& delta;K-41 = -0.12 & PLUSMN; 0.58 & PTSTHOUSND;) and kidneys (& delta;K-41 = -0.24 & PLUSMN; 0.57 & PTSTHOUSND;). We found that the K isotopic and concentration variability is mostly controlled by the organs, with a minor effect of the genetic background and sex. Our study suggests that the K isotopic composition could be used as a biomarker for changes in K+ homeostasis and related diseases such as hypertension, cardiovascular, and neurodegenerative diseases.
WOS关键词CALCIUM ; SODIUM ; COPPER ; FRACTIONATION ; HYPERTENSION ; EXCRETION ; LEVEL ; RATIO ; MASS ; FE
资助项目Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; IPGP multidisciplinary program PARI ; Horizon ERC DAI[101059236] ; University of Chinese Academy of Sciences
WOS研究方向Biochemistry & Molecular Biology
语种英语
出版者OXFORD UNIV PRESS
WOS记录号WOS:001025980800001
资助机构Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; Mission for Transversal and Interdisciplinary Initiatives (MITI) from CNRS through the defi ISOTOP ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; IPGP multidisciplinary program PARI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; Horizon ERC DAI ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences ; University of Chinese Academy of Sciences
源URL[http://ir.iggcas.ac.cn/handle/132A11/111282]  
专题地质与地球物理研究所_中国科学院矿产资源研究重点实验室
通讯作者Moynier, Frederic
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.James Cook Univ, Earth & Environm Sci, Douglas, Australia
3.Univ Paris Cite, Paris, France
4.Univ Sorbonne Paris Nord, INSERM, LVTS, F-75018 Paris, France
5.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Mineral Resources, Beijing 100029, Peoples R China
6.Univ Paris Cite, Inst Phys Globe Paris, CNRS, 1 Rue Jussieu, F-75005 Paris, France
推荐引用方式
GB/T 7714		 Cui, Meng-Meng,Moynier, Frederic,Su, Ben-Xun,et al. Stable potassium isotope distribution in mouse organs and red blood cells: implication for biomarker development[J]. METALLOMICS,2023,15(7):11.
APA Cui, Meng-Meng.,Moynier, Frederic.,Su, Ben-Xun.,Dai, Wei.,Hu, Yan.,...&Le Borgne, Marie.(2023).Stable potassium isotope distribution in mouse organs and red blood cells: implication for biomarker development.METALLOMICS,15(7),11.
MLA Cui, Meng-Meng,et al."Stable potassium isotope distribution in mouse organs and red blood cells: implication for biomarker development".METALLOMICS 15.7(2023):11.

入库方式： OAI收割

来源：地质与地球物理研究所

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