Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease
文献类型:期刊论文
作者 | Lyu, Yan2; Wang, Yu2; Guo, Jianyou1; Wang, Yuqing2; Lu, Yifan2; Hao, Zhuangzhuang2; Jiang, Tingyue2; Fan, Wenxin2; Li, Yihua2; Shi, Jinli2 |
刊名 | FRONTIERS IN AGING NEUROSCIENCE |
出版日期 | 2023-11-22 |
卷号 | 15页码:20 |
通讯作者邮箱 | chenyanlong@gzucm.edu.cn (y. chen) ; zyfsliao@gzucm.edu.cn (q. liao) |
ISSN号 | 1663-4365 |
关键词 | Corydalis Rhizoma Alzheimer's disease serum pharmacochemistry network pharmacological neuroinflammation polarization type of BV2 JAK2/STAT3 |
DOI | 10.3389/fnagi.2023.1285549 |
产权排序 | 1 |
文献子类 | 综述 |
英文摘要 | BackgroundAlzheimer's disease (AD) is a multifactorial neurodegenerative condition. The search for multi-target traditional Chinese medicines or ingredients for treating AD has attracted much attention. Corydalis rhizome (CR) is a traditional Chinese medicine. Its main components are alkaloids, which have therapeutic effects that can potentially be used for treating AD. However, no systematic study has been conducted to explore the anti-AD efficacy of CR, as well as its active compounds and mechanisms of action.ObjectiveThe present study aimed to clarify CR's active constituents and its pharmacological mechanisms in treating AD.MethodsA D-galactose & scopolamine hydrobromide-induced AD mouse model was used and CR was administered orally. The prototypical alkaloid components were identified in the serum. The core components, key targets, and possible mechanisms of action of these alkaloids were revealed through network pharmacology. Molecular docking of the key target was performed. Finally, the mechanism was validated by lipopolysaccharide (LPS)-induced activation of BV2 microglia.ResultsThe results showed that CR improved anxiety-like behavior, spatial and non-spatial recognition, and memory capacity in AD mice. It also achieved synergistic AD treatment by modulating neurotransmitter levels, anti-neuroinflammation, and anti-oxidative stress. The core components that enhance CR's efficacy in treating AD are protoberberine-type alkaloids. The CR may induce the polarization of LPS-activated BV2 microglia from phenotype M1 to M2. This is partially achieved by modulating the IL-6/JAK2/STAT3 signaling pathway, which could be the mechanism by which CR treats AD through anti-inflammation.ConclusionThe present study provided a theoretical and experimental basis for the clinical application of CR in treating AD. It also provides information that aids the secondary development, and precise clinical use of CR. |
收录类别 | SCI |
WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; MEMORY ; MODEL ; SCOPOLAMINE ; HIPPOCAMPUS ; INHIBITION |
资助项目 | National Natural Science Foundation of China10.13039/501100001809 |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:001115320600001 |
资助机构 | National Natural Science Foundation of China10.13039/501100001809 |
源URL | [http://ir.psych.ac.cn/handle/311026/46591] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Shi, Jinli |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Lyu, Yan,Wang, Yu,Guo, Jianyou,et al. Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2023,15:20. |
APA | Lyu, Yan.,Wang, Yu.,Guo, Jianyou.,Wang, Yuqing.,Lu, Yifan.,...&Shi, Jinli.(2023).Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease.FRONTIERS IN AGING NEUROSCIENCE,15,20. |
MLA | Lyu, Yan,et al."Integrating serum pharmacochemistry and network pharmacology to reveal the active constituents and mechanism of Corydalis Rhizoma in treating Alzheimer's disease".FRONTIERS IN AGING NEUROSCIENCE 15(2023):20. |
入库方式: OAI收割
来源:心理研究所
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