Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms
文献类型:期刊论文
作者 | Bian, Li-hua2,3; Wang, Si-qi1,2; Li, Wen-jing1,2; Li, Jie1,2; Yin, Yi1,2; Ye, Fang-fu2,3; Guo, Jian-you1 |
刊名 | BIOMEDICINE & PHARMACOTHERAPY |
出版日期 | 2023-12-31 |
卷号 | 169页码:11 |
通讯作者邮箱 | psyguojy@163.com (j.y. guo) |
ISSN号 | 0753-3322 |
关键词 | Depression Cryptotanshinone 16 S rDNA Transcriptomics PI3K-AKT pathway |
DOI | 10.1016/j.biopha.2023.115921 |
产权排序 | 3 |
文献子类 | 综述 |
英文摘要 | Cryptotanshinone (CPT), a bioactive compound derived from the traditional Chinese herb Salvia miltiorrhiza, exhibits promising antidepressant properties. Employing a rat model subjected to Chronic Unpredictable Mild Stress (CUMS), behavioral analyses (open field experiment, elevated cross maze experiment, sugar water preference experiment, forced swimming experiment) and inflammatory factor assessments were conducted to assess the efficacy of CPT in alleviating depressive symptoms and inflammatory responses induced by CUMS. Moreover, 16 S rDNA analysis revealed alterations in the gut microbiota of rats exposed to both CUMS and CPT administration. Notably, CPT administration was found to mitigate harmful bacterial shifts associated with depression. Preliminary exploration of the molecular mechanism underlying CPT's antidepressant effects via transcriptomics analysis and molecular docking indicated that CPT might exert its influence by regulating the PI3K-AKT pathway. This study sheds light on the potential therapeutic role of CPT in managing depressive disorders, offering a comprehensive understanding of its impact on behavior, inflammation, gut microbiota, and molecular pathways. |
收录类别 | SCI |
WOS关键词 | STRESS ; MODELS |
资助项目 | National Natural Science Founda-tion of China[12090054] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX] |
WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
WOS记录号 | WOS:001126204500001 |
资助机构 | National Natural Science Founda-tion of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
源URL | [http://ir.psych.ac.cn/handle/311026/46691] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Guo, Jian-you |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A DatunRd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Bian, Li-hua,Wang, Si-qi,Li, Wen-jing,et al. Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,169:11. |
APA | Bian, Li-hua.,Wang, Si-qi.,Li, Wen-jing.,Li, Jie.,Yin, Yi.,...&Guo, Jian-you.(2023).Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms.BIOMEDICINE & PHARMACOTHERAPY,169,11. |
MLA | Bian, Li-hua,et al."Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms".BIOMEDICINE & PHARMACOTHERAPY 169(2023):11. |
入库方式: OAI收割
来源:心理研究所
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