中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder

文献类型:期刊论文

作者Jiang, Jin9,10,11; Wan, Ke9,10,11; Liu, Yueling9,10,11; Tang, Yan9,10,11; Tang, Wenxin7,8; Liu, Jian7,8; Ma, Jiehua7,8; Xue, Chuang7,8; Chen, Lu9,10,11; Qian, Huichang5,6
刊名NEURAL PLASTICITY
出版日期2023-12-07
卷号2023页码:8
通讯作者邮箱jigongjun@163.com (gongjun ji) ; ayswallow@126.com (chunyan zhu)
ISSN号2090-5904
DOI10.1155/2023/2741287
产权排序6
文献子类实证研究
英文摘要

Background. Obsessive-compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This study investigated whether an accelerated high-dose theta burst stimulation (ahTBS) protocol significantly improves the efficacy of OCD compared to traditional 1-Hz repetitive transcranial magnetic stimulation (rTMS) in the routine clinical setting. Method. Forty-five patients with OCD were randomized into two groups and treated with ahTBS or 1-Hz rTMS for 5 days. Patients were assessed at baseline at the end of treatment using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Results. After 5 days of treatment, there was a significant decrease in Y-BOCS scores in both groups (p<0.001), and the difference between the two groups was not statistically significant (group x time interaction, F = 1.90, p=0.18). There was also no statistically significant difference in other secondary outcome indicators, including depression, anxiety symptoms, and response rate. However, the ahTBS group had a greater trend in response rate. Neuropsychological testing showed no negative cognitive side effects of either treatment. Conclusion. Accelerated high-dose TBS is as safe and has comparable short-term efficacy to traditional 1-Hz rTMS for the clinical treatment of OCD. Further research is needed to explore optimal ahTBS parameters, validate the utility of this treatment modality, and identify factors predictive of rapid clinical response to guide clinical decision-making. This trial is registered with NCT05221632.

收录类别SCI
WOS关键词TRANSCRANIAL MAGNETIC STIMULATION ; METAANALYSIS ; TRIAL
资助项目National Natural Science Foundation of China ; Major Program of the National Natural Science Foundation of China[82090034] ; University Synergy Innovation Program of Anhui Province[GXXT-2021-003] ; [32271134] ; [81771456] ; [31970979]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001126025600001
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; Major Program of the National Natural Science Foundation of China ; University Synergy Innovation Program of Anhui Province
源URL[http://ir.psych.ac.cn/handle/311026/46697]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Ji, Gongjun; Zhu, Chunyan
作者单位1.Anhui Med Univ, Dept Psychol, Affiliated Hosp 2, Hefei, Peoples R China
2.Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei, Peoples R China
3.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China
4.Zhejiang Sci Tech Univ, Dept Psychol, Hangzhou, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Lab Traumat Stress Studies, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
7.Zhejiang Univ, Hangzhou Peoples Hosp 7, Sch Med, Hangzhou, Peoples R China
8.Zhejiang Univ, Affiliated Mental Hlth Ctr, Sch Med, Hangzhou, Peoples R China
9.Anhui Prov Key Lab Cognit & Neuropsychiat Disorder, Hefei, Peoples R China
10.Collaborat Innovat Ctr Neuropsychiat Disorders & M, Hefei, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Jin,Wan, Ke,Liu, Yueling,et al. A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder[J]. NEURAL PLASTICITY,2023,2023:8.
APA Jiang, Jin.,Wan, Ke.,Liu, Yueling.,Tang, Yan.,Tang, Wenxin.,...&Zhu, Chunyan.(2023).A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder.NEURAL PLASTICITY,2023,8.
MLA Jiang, Jin,et al."A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder".NEURAL PLASTICITY 2023(2023):8.

入库方式: OAI收割

来源:心理研究所

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