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Machine learning and experimental screening of chromatin regulator signatures and potential drugs in hepatitis B related hepatocellular carcinoma

文献类型：期刊论文

作者Jia, Caixia6; Chen, Jianxin6; Wang, Xueting5; Yang, Xingliang6; Wu, Hongxing6; Chen, Aiping6; Li, Jingzhong2,6; Zhang, Kunlin1,3,4
刊名JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
出版日期2023-12-14
页码15
ISSN号0739-1102
关键词Chromatin regulators hepatitis B related HCC immune HepG2.2.15 potential drugs resveratrol
DOI10.1080/07391102.2023.2295382
通讯作者Li, Jingzhong(lijz@bucm.edu.cn) ; Zhang, Kunlin(zhangkunlin@psych.ac.cn)
英文摘要Many evidences have confirmed that chromatin regulator factors (CRs) are involved in the progression of cancer, but its potential mechanism of affecting hepatitis B related hepatocellular carcinoma still needs to be studied. Our study detected the CRs that affect hepatitis B related hepatocellular carcinoma (HBV-HCC) through machine learning analysis, conducted the analysis of immune cells, constructed the relevant risk model and immune function infiltration, and predicted the potential therapeutic drugs. We found that these CRs were significantly related to the immune cells of Macrophages, B cells, CD8+T cells, etc., and PBK, AURKA, TOP2A and AURKB were the potential risk CRs of HBV-HCC. The expression levels of these four CRs increased in HepG2.2.15 cells and the liver of HBV-HCC patients, consistent with the predicted risk model. Subsequently, ten potential drugs closely related to the risk CRs were finally obtained, experimental research on resveratrol has shown that it can inhibit the proliferation of HepG2.2.15 cells and potentially inhibit the occurrence and development of HBV-HCC. Our study provides novel insights into the function of CRs in HBV-HCC and certain ideas for more accurate targeted therapy.Communicated by Ramaswamy H. Sarma
收录类别SCI
WOS关键词GENE-EXPRESSION ; CANCER ; IDENTIFICATION ; BIOMARKERS ; ANTIBODY ; KINASE ; CELLS ; RISK
资助项目National Natural Science Foundation of China[82174237]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
出版者TAYLOR & FRANCIS INC
WOS记录号WOS:001127350100001
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/46703]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Jingzhong; Zhang, Kunlin
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Genet & Biomed Informat Res, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Beijing Univ Chinese Med, Bei San Huan East Rd, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Hebei Univ, Coll Chem & Environm Sci, Key Lab Analyt Sci & Technol Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Hebei, Peoples R China
6.Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Caixia,Chen, Jianxin,Wang, Xueting,et al. Machine learning and experimental screening of chromatin regulator signatures and potential drugs in hepatitis B related hepatocellular carcinoma[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2023:15.
APA Jia, Caixia.,Chen, Jianxin.,Wang, Xueting.,Yang, Xingliang.,Wu, Hongxing.,...&Zhang, Kunlin.(2023).Machine learning and experimental screening of chromatin regulator signatures and potential drugs in hepatitis B related hepatocellular carcinoma.JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,15.
MLA Jia, Caixia,et al."Machine learning and experimental screening of chromatin regulator signatures and potential drugs in hepatitis B related hepatocellular carcinoma".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023):15.

入库方式： OAI收割

来源：心理研究所

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