The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression
文献类型:期刊论文
作者 | Wen, Lulu4; Yan, Chuming4; Si, Tong2; Huang, Liyuan4; Nie, Yuting4; Shen, Huixin4; Qu, Miao4; Zhang, Xiangyang1,3 |
刊名 | JOURNAL OF AFFECTIVE DISORDERS |
出版日期 | 2024-02-15 |
卷号 | 347页码:469-476 |
通讯作者邮箱 | qumiao@xwhosp.org (m. qu) ; zhangay@psych.ac.cn (x. zhang) |
ISSN号 | 0165-0327 |
关键词 | Post stroke depression Cytokines Oxidative stress Biomarker Inflammation |
DOI | 10.1016/j.jad.2023.12.012 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Backgrounds: Chronic inflammation and oxidative stress play an important role in the pathogenesis of PSD. The main purposes of this study were to examine the dynamic changes of cytokines networks in PSD and the predictive role of early inflammation and oxidative stress for 2-week PSD.Methods: Patients with ischemic stroke were recruited on day 3, and those with Hamilton Depression Rating Scale 24-Item (HAMD-24) >= 8 were classified as ischemic stroke patients with depressive symptoms and others as ischemic stroke patients without depressive symptoms. Subjects were then followed up at 2 weeks and 3 months, with those meeting diagnostic criteria for depressive symptoms on the HAMD >= 8 and the Statistical Manual of Mental Disorders-V (DSM-V) as the PSD group, and the others as the non-PSD group.Results: At 3 days, IFN-gamma, IL-12(p70), IL-12(p40), IL-2, IL-28A/IFN lambda 2, and IL-19 were elevated in ischemic stroke patients with depressive symptoms. At 2 weeks, IL-12(p40), IL-19, IL-22, IFN-beta and MMP-1 all were increased in PSD patients. At 3 months, IL-2, IFN-beta and sCD163 increased in PSD group. Longitudinally, the inflammatory response decreased significantly in PSD group from 2 weeks to 3 months of follow-up, while it gradually decreased in non-PSD group from 3 days to 3 months of follow-up. SOD was positively related to IL-12(p70), IFN-gamma and IL-20. Plasma IFN-gamma at 3 days may be a potential predictive biomarker for 2-week PSD.Conclusions: Peripheral inflammation and oxidative stress are involved in the pathogenesis of PSD, providing new insights for its diagnosis and treatment. |
收录类别 | SCI ; SSCI |
WOS关键词 | BRAIN INFLAMMATION ; SERUM-LEVELS ; RAT MODEL ; STROKE ; ASSOCIATION ; TH1 ; SYMPTOMS |
资助项目 | National Natural Science Founda-tion of China[81973759] ; National Natural Science Founda-tion of China[82274444] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:001134020800001 |
资助机构 | National Natural Science Founda-tion of China |
源URL | [http://ir.psych.ac.cn/handle/311026/46753] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Qu, Miao; Zhang, Xiangyang |
作者单位 | 1.16 Lincui Rd, Beijing 100101, Peoples R China 2.Beijing Shijitan Hosp, Neurol Dept, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Capital Med Univ, Neurol Dept, Xuan Wu Hosp, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wen, Lulu,Yan, Chuming,Si, Tong,et al. The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,347:469-476. |
APA | Wen, Lulu.,Yan, Chuming.,Si, Tong.,Huang, Liyuan.,Nie, Yuting.,...&Zhang, Xiangyang.(2024).The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression.JOURNAL OF AFFECTIVE DISORDERS,347,469-476. |
MLA | Wen, Lulu,et al."The predictive role of early inflammation and oxidative stress and the dynamics of cytokines networks in post-stroke depression".JOURNAL OF AFFECTIVE DISORDERS 347(2024):469-476. |
入库方式: OAI收割
来源:心理研究所
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