前额叶海马环路支持序列工作记忆的神经机制
文献类型：学位论文
| 作者 | 苏明宏 |
| 答辩日期 | 2023-12 |
| 文献子类 | 博士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 叶铮 |
| 关键词 | 前额叶 海马 序列工作记忆 神经振荡 |
| 学位名称 | 理学博士 |
| 学位专业 | 认知神经科学 |
| 其他题名 | The neural mechanisms of how prefrontal-hippocampal circuits support sequential working memory |
| 中文摘要 | During our daily lives and work, we often need to think for ourselves in what order and in what way, rather than simply repeating what is already there, in order to perform complex tasks. For example, when trying to make a delicious meal, we not only need to put in the dishes and seasonings in the right order, but also need to be precise about the heat and the amount of seasoning. Sequential working memory happens to be the cognitive function that helps us precisely manipulate and maintain the order and content of multiple pieces of information. It has been shown that the prefrontal and hippocampus support learning and memory of information, but whether and how prefrontal hippocampal circuits support the online manipulation and maintenance of sequential information remains unknown. This thesis is divided into three parts to answer these questions. In the first part, three behavioral experiments were conducted to illustrate that maintenance and manipulation of sequential information are not isolated. When we are reordering multiple pieces of information, the accuracy of remembering individual pieces of information decreases. In the second part and the third part, the intracranial local field potential recording experiments based on stereo-electroencephalography (SEEG) show that theta and gamma oscillations are crucial for the prefrontal hippocampal circuits to engage in sequence working memory. There are general and specific neural mechanisms for manipulating and maintaining sequence information. The second part (experiment 4) was based on a line ordering task to investigate how the prefrontal hippocampal circuits support the online updating and generation of sequence information. Participants showed longer thinking times and more recall errors when asked to arrange random lines clockwise (random trials) than to maintain ordered lines (ordered trials) before recalling the orientation of a particular line. Compared with the ordered trials, first, the theta power in the prefrontal cortex increased substantially. The theta power increased transiently and was correlated with the memory precision of line orientation. Second, theta phase coherences between the dorsal lateral prefrontal cortex (DLPFC) and hippocampus were enhanced for ordering, especially for more precisely memorized lines. Third, the theta band DLPFC令hippocampus influence was selectively enhanced for ordering. Finally, gamma oscillations of lateral-prefrontal-hippocampal circuits represent the newly generated sequential information. In the third part, the other SEEG study (experiment 5) investigated whether ordering-related neural activity in prefrontal hippocampal circuits was also affected by memory load during maintenance. Participants also showed longer thinking times and more recall errors when asked to maintain four lines (load 4) than to maintain two lines (load 2) before recalling the orientation of a particular line. First, compared with load 2, only the dorsal anterior cingulate cortex (dACC) showed higher theta power and was not associated with memory precision. Second, theta phase coherences between the DLPFC and hippocampus, between the dACC and hippocampus were higher at load 4 but was not affected by the memory precision. Third, the direction of the information flow was from the hippocampus to the DLPFC and dACC in all memory loads. Finally, the representative similarity of sequences by gamma oscillations increased with memory load in the hippocampus and ventral lateral prefrontal cortex and decreased with memory load in the dACC. This study suggests that the DLPFC and hippocampus may support the online manipulation of sequence information through theta oscillations. Besides, the lateral prefrontal-hippocampal circuits may support the generation of new sequence information through gamma oscillations. Overall, theta coherence in prefrontal and hippocampus was generalized in the maintenance and manipulation of sequence working memory, but directional effects were specific. More importantly, this study reveals for the first time that the prefrontal-hippocampal circuits supports online processing of time-series information through theta and gamma oscillations and confirms that the prefrontal-hippocampal circuits play a key role in temporal cognition, which provides a new research direction for traditional hippocampal and spatial cognition. |
| 英文摘要 | 在日常生活和工作中，我们往往需要自己思考按什么顺序和方式，而不是简单的重复已有的内容，才能完成复杂的工作。比如当想做好一道菜时，我们不但需要以正确的顺序放入菜和调味料，而且需要精确的掌握好火候和调料的用量。序列工作记忆恰好是帮助我们精确的操作和保持多个信息的顺序和内容的认知功能。已有研究表明前额叶和海马支持我们学习和保持信息，但前额叶海马环路是否以及如何支持序列信息的在线操作和保持仍然是未知的。本论文分三部分来回答这个问题。第一部分以3个行为实验，说明序列信息的保持和操作不是孤立的。当我们在给多个信息重新排序时，对单个信息的记忆精确度会降低。第二部分和第三部分基于立体脑电图的颅内局部场电位记录实验，发现theta和gamma 振荡是前额叶海马环路参与序列工作记忆的关键，并且在操作和保持序列信息时具有普遍性和特异性。第二部分(实验4)基于线条排序任务，研究人脑前额叶海马环路如何支持序列信息的及时更新和生成。行为表现上，参与者顺时针排列4个随机出现的线条(随机排序条件)，比记住已经顺时针排列的线条(川页序保持条件)时表现出更长的思考时间和更多的回忆错误。神经机制上，与保持条件相比，首先，排序条件下前额叶的theta功率持续增加，海马的theta功率瞬时增加并且与线条方向的记忆精确度相关。其次，排序时背外侧前额叶和海马体之间的theta相位一致性增强，并且有助于更准确的记忆线条方向。第三，排序时theta振荡从背外侧前额叶到海马的方向性影响增强。最后，外侧前额叶海马环路的gamma振荡能表征新生成的序列信息。第三部分(实验5)研究了前额叶海马环路中排序相关的神经活动是否也受记忆负荷的影响。行为表现上，参与者在负荷4 (4个线条)比负荷2 (2个线条)也表现出更长的思考时间和更多的回忆错误。神经机制上，与负荷2相比，第一，只有背侧前扣带回的theta功率在负荷4更高，且不受信息记忆精确度的影响。第二，背外侧前额叶和背侧前扣带回与海马的theta振荡相位一致性在负荷4也更高，但不受信息记忆精确度的影响。第三，信息流动的方向均为从海马到前额叶。最后，海马和腹外侧前额叶的gamma振荡对序列的表征相似性随着负荷增加，背侧前扣带回的gamma振荡对序列的表征相似性随着负荷增加而下降。总体来说，在序列工作记忆的保持和操作中，前额叶和海马的theta一致性是普遍的，但方向性影响是特异性的。更重要的是，这项研究首次揭示了前额一海马环通过theta和gamma振荡支持时间序列信息的在线加工，并证实了前额一海马环路在时间认知中起着关键作用，这为传统的海马和空间认知提供了一个新的研究方向。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46605]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 推荐引用方式 GB/T 7714 | 苏明宏. 前额叶海马环路支持序列工作记忆的神经机制[D]. 中国科学院心理研究所. 中国科学院大学. 2023. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。