儿童ADHD倾向个体的脑电频谱及生物反馈训练研究
文献类型：学位论文
| 作者 | 宋洁 |
| 答辩日期 | 2023-06 |
| 文献子类 | 硕士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 李雪冰 |
| 关键词 | 脑电生物反馈 脑电频谱 注意缺陷多动障碍 Theta/beta Theta/SMR |
| 学位名称 | 理学硕士 |
| 学位专业 | 发展与教育心理学 |
| 其他题名 | EEG spectrum analysis and neurobiofeedback training in ADHD一prone children |
| 中文摘要 | Attention Deficit Hyperactivity Disorder (ADHD) has become one of the most common neurodevelopmental and mental disorders in children and adolescents, the early screening indicators and intervention methods for ADHD are the current focus of research issues. In this study, through the comparative analysis of the spectral features of resting-state electroencephalogram (EEG) between children with ADHD-prone and healthy children, the study aimed to demonstrate the differential patterns of theta/beta(θ/β)and theta/sensory motor rhythm (θ/SMR) ratios in different brain regions of children with ADHD-prone. Additionally, EEG biofeedback technology was used to treat children with ADHD-prone in different brain regions, and compare the changes of θ/βand θ/ SMR before and after training, and determine an effective intervention protocol. In Study 1，we screened children aged 6-12 years using ADHD Rating Scale-IV: Home Version, ADHD RS-IV and Integrated Visual and Auditory Continuous Performance Test, IVA-CPT, ultimately, we recruited 22 individuals with ADHD-prone and 25 healthy controls. EEG signals were collected during both eyes-closed and eyes-open resting states, We analyzed the spectral differences in theta sensory motor rhythm (SMR), and beta frequencies in the prefrontal (Fp1) and central (FCz) regions of the brain for both groups. We also examined the discriminative significance of the theta/beta and theta/SMR ratios. The results revealed significant main effects of the EEG recording state, indicating that spectral power and ratios were higher during the eyes-closed state compared to the eyes-open state. Additionally, there were main effects of electrode sites, indicating spectral differences between the prefrontal and central regions. The more interesting result is that there was only a significant group difference in the SMR values at FCz, which showed lower power in the ADHD-prone group than in the healthy control group. In Study 2, using the same screening tools and inclusion criteria as in Study 1，we recruited 40 children with ADHD-prone and randomly assigned them into two groups. Group 1 received real-time neurofeedback training to enhance SMR spectral power at the FCz electrode. The training sessions were conducted 2-3 times per week, with each session lasting approximately 40 minutes一a total of 30 training sessions. Group 2 received the same training protocol but targeted the Fpl electrode instead of FCz. Apre-test and post-test design was employed in this study, and we collected data on the theta/beta and theta/SMR ratios, as well as the results from the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT), before and after the intervention for both groups. The results showed that after 30 sessions of SMR neurofeedback intervention, both groups exhibited a significant decrease in the theta/beta ratio. There were between-group differences in the theta/SMR ratio, with a significant decrease observed at the FCz electrode (Group 1), while the decrease at the Fp1 electrode (Group 2) was not significant. After the feedback training, both groups showed improvements in the overall response control quotient and overall attention quotient in the IVA-CPT test. In conclusion, the fine-grained analysis of the prefrontal and central electrodes and the targeted neurofeedback intervention at different electrode sites for individuals with ADHD-prone yielded distinct results. Specifically, the SMR spectral power at the FCz electrode showed better discriminative ability between children with ADHD-prone and healthy children. Similarly, by enhancing the SMR spectral power through training, the intervention targeting the FCz electrode in the posterior part of the prefrontal region demonstrated better improvements in the EEG of children with ADHD-prone compared to the intervention targeting the Fp1 electrode in the anterior part of the prefrontal region. This study provides insights into the use of EEG techniques for better identification and intervention in children with ADHD. |
| 英文摘要 | 注意缺陷多动障碍(Attention Deficit Hyperactivity Disorder, ADHD)已经成为儿童青少年最常见的神经发育和精神疾病之一，其早期的筛查指标及干预方法是当前的重点研究问题。本研究通过对比分析ADHD倾向儿童和健康儿童静息态下脑电的频谱特征，论证theta/beta(θ/β)、theta/SMR ( θ/SMR) (感觉运动节律sensory motor rhythm, SMR)比值在ADHD倾向儿童不同脑区的差异性，并在不同脑区采用脑电生物反馈技术对ADHD倾向儿童进行干预治疗，对比θ/β、θ/SMR在训练前后的变化，确定合理的干预方案。 研究一，我们采用ADHD评定量表IV家庭版量表(ADHD Rating Scale-IV:Home Version, ADHD RS-IV)和视听整合持续性操作测验(Integrated Visual and Auditory Continuous Performance Test IVA-CPT)对6-12岁儿童进行筛查，最后招募了22名ADHD倾向个体和25名健康对照，分别采集其闭眼和睁眼静息态下的脑电信号，分析两组被试额叶前端后端(Fp1和FCz)的θ, SMR,β夕久须谱差异，以及θ/β和θ/SMR比值的区分意义。结果发现，以上所有频谱及比值都存在明显脑电采集状态的主效应，表现为闭眼状态的频谱功率及比值大于睁眼状态的。同时也普遍存在电极点位的主效应，额叶前部和后部采集的频谱有所差异。更为有趣的结果是，只有在FCz点的SMR值存在显著的组间差异，表现为ADHD倾向组的功率低于健康对照组。 研究二采用和研究一相同的筛查工具及入组标准，招募ADHD倾向儿童40人，随机分为两组，组1针对FCz点位采集到的实时脑电进行提升SMR频谱功率的反馈训练，每周2-3次，每次约40分钟，总共训练30次;组2针对Fp1点位采集到的实时脑电进行提升SMR频谱功率的反馈训练，与组1的训练频次和时长等同。本研究采用随机分组前后测设计，采集两组治疗前后的θ/β , θ/SMR比值，及视听整合持续性操作测验(IVA-CPT)数据。结果发现，经过30次提升SMR神经生物反馈干预后，两组在哪比值上均有显著降低。在θ/SMR比值上存在组间差异，在FCz点位(组1)干预后比值显著降低，在Fp1点位(组2)干预后比值降低不显著。经过反馈训练后，两组在IVA-CPT测验中综合反应控制商数和综合注意力商数均有所改善。 总的来说，细化额叶前部和后部电极点进行脑电频谱分析以及针对不同电极点对ADHD倾向个体进行生物反馈干预确实有所不同。主要表现为FCz点SMR频谱功率能更好的区分ADHD倾向和健康儿童，同样通过提升SMR频谱训练，以额叶后部的FCz点为干预点位在ADHD倾向儿童的脑电改善上也优于额叶前部的Fpl电位。该研究为采用脑电技术更好的鉴别和干预ADHD儿童有着一定的启示作用。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/46665]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 推荐引用方式 GB/T 7714 | 宋洁. 儿童ADHD倾向个体的脑电频谱及生物反馈训练研究[D]. 中国科学院心理研究所. 中国科学院大学. 2023. |
入库方式： OAI收割
来源：心理研究所
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