Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR
文献类型：期刊论文
| 作者 | Guo, Pengju2,3; Chen, Tong1,2; Hu, Xianggang1,2; Duan, Yelin1,2; Zheng, Liu2; Du, Gaoxiang1,2; Wang, Qing1,2; Ding, Aoxue2; Qin, Guoqing2; Chen, Yihan1,2 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2024 |
| 卷号 | 142页码:13 |
| ISSN号 | 0045-2068 |
| 关键词 | Chloranthus japonicas Lindenane sesquiterpenoid dimers PCSK9 LDLR |
| DOI | 10.1016/j.bioorg.2023.106958 |
| 通讯作者 | Wang, Wenqiong(wenqiong1019@simm.ac.cn) ; Mu, Qing(muqing@fudan.edu.cn) ; Xuan, Lijiang(ljxuan@simm.ac.cn) |
| 英文摘要 | UPLC-TOF-MS/MDF directed phytochemical research of Chloranthus japonicus led to the isolation of 46 lindenane sesquiterpenoid dimers, which included 13 new analogs. Their structures with absolute configurations were elucidated by analysis of spectroscopic data. Fourteen compounds with ester chains significantly decreased PCSK9 protein level in medium of HepG2 cells, especially for compounds 14 and 29 (5 mu M) with inhibition rates of 69.0% and 72.8%, respectively. Compound 14 in HepG2 cells was evaluated via DiI-LDL uptake assays and found to increase LDL uptake by upregulating LDLR mRNA and protein level. Meanwhile, 14 decreased the secretion of PCSK9 protein in medium and downregulated intracellular PCSK9 protein and mRNA level. The discovery of these natural small molecule compounds provides a novel structure basis for design PCSK9 regulators, making them a promising lead for development of new lipid-lowering agents. |
| WOS关键词 | CHEMICAL-CONSTITUENTS ; C-F ; PLANTS ; ROOTS ; CHLORAHOLOLIDE ; BLOCKERS ; POTENT |
| 资助项目 | Youth Innovation Promotion Association[SIMM1601ZZ-03] ; Shanghai Municipal Science and Technology Major Project[2019284] ; [TM202301L001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:001116928600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308092]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wenqiong; Mu, Qing; Xuan, Lijiang |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Pengju,Chen, Tong,Hu, Xianggang,et al. Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR[J]. BIOORGANIC CHEMISTRY,2024,142:13. |
| APA | Guo, Pengju.,Chen, Tong.,Hu, Xianggang.,Duan, Yelin.,Zheng, Liu.,...&Xuan, Lijiang.(2024).Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR.BIOORGANIC CHEMISTRY,142,13. |
| MLA | Guo, Pengju,et al."Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR".BIOORGANIC CHEMISTRY 142(2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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