TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway
文献类型：期刊论文
| 作者 | Wang, Chun5; Han, Mengyao5; Li, Xinhang5; Lv, Jie5; Zhuang, Wei3,4,5; Xie, Ling5; Liu, Guangyu5; Saimaier, Kaidireya5; Han, Sanxing5; Shi, Changjie5 |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2023-12-01 |
| 卷号 | 125页码:13 |
| ISSN号 | 1567-5769 |
| 关键词 | AIH T cell Pro-inflammatory IFN-gamma PI3K-AKT |
| DOI | 10.1016/j.intimp.2023.111110 |
| 通讯作者 | Wang, Guiying(wgy@tongji.edu.cn) ; Du, Changsheng(ducs2015@163.com) |
| 英文摘要 | Autoimmune hepatitis (AIH) is an inflammatory liver disease in which the autoimmune system instigates an attack on the liver, causing inflammation and liver injury, and its incidence has increased worldwide in recent years. The mouse model of acute hepatitis established by concanavalin A (Con A) is a typical and recognized mouse model for the study of T-cell-dependent liver injury. In this study, we aimed to investigate whether the artemisinin derivative TPN10475 could alleviate AIH and its possible mechanisms. TPN10475 effectively inhibited lymphocyte proliferation and IFN-gamma+ T cells production in vitro, alleviated liver injury by decreasing infiltrating inflammatory T cells producing IFN-gamma in the liver and peripheral immune tissues, and demonstrated that TPN10475 weakened the activation and function of T cells by inhibiting PI3K-AKT signaling pathway. These results suggested that TPN10475 may be a potential drug for the treatment of AIH, and the inhibition of PI3KAKT signaling pathway may provide new ideas for the study of the pathogenesis of AIH. |
| WOS关键词 | LIVER-INJURY ; IFN-GAMMA ; MICE ; MECHANISMS |
| 资助项目 | National Natural Science Foundation of China[32070768] ; National Natural Science Foundation of China[32270754] ; National Natural Science Foundation of China[32270591] ; National Natural Science Foundation of China[32070617] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:001109696800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308104]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Guiying; Du, Changsheng |
| 作者单位 | 1.Tongji Univ, Sch Life Sci & Technol,Natl Stem Cell Translat Res, Clin & Translat Res Ctr,Shanghai First Matern & In, Frontier Sci Ctr Stem Cell Res,Shanghai Key Lab Si, Shanghai 200092, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Tongji Univ, Putuo Peoples Hosp, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chun,Han, Mengyao,Li, Xinhang,et al. TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2023,125:13. |
| APA | Wang, Chun.,Han, Mengyao.,Li, Xinhang.,Lv, Jie.,Zhuang, Wei.,...&Du, Changsheng.(2023).TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway.INTERNATIONAL IMMUNOPHARMACOLOGY,125,13. |
| MLA | Wang, Chun,et al."TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway".INTERNATIONAL IMMUNOPHARMACOLOGY 125(2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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