Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism
文献类型:期刊论文
作者 | Guo, Xiaozhen8; Wang, Jiawen7,8; Xu, Hualing6,8; Wang, Yangyang5,8; Cao, Yutang6,8; Wen, Yingquan4,8; Li, Jiaqi3,8; Liu, Yameng8; Wang, Kanglong8; Wang, Jue8 |
刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS |
出版日期 | 2024 |
卷号 | 1869期号:1页码:13 |
ISSN号 | 1388-1981 |
关键词 | Diurnal rhythm Insulin sensitivity Obesity Gut microbiota Ursodeoxycholic acid |
DOI | 10.1016/j.bbalip.2023.159419 |
通讯作者 | Xu, Lingyan(lyxu@bio.ecnu.edu.cn) ; Xie, Cen(xiecen@simm.ac.cn) |
英文摘要 | The disruption of the diurnal rhythm has been recognized as a significant contributing factor to metabolic dysregulation. The important role of gut microbiota and bile acid metabolism has attracted extensive attention. However, the function of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis remains largely unknown. Herein, we aimed to investigate the interplay between rhythmicity of host metabolism and gut microbiota-bile acid axis, as well as to assess the impact of obesity on them. We found that high fat diet feeding and Leptin gene deficiency (ob/ob) significantly disturbed the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The bile acid profiling unveiled a conspicuous diurnal rhythm oscillation of ursodeoxycholic acid (UDCA) in lean mice, concomitant with fluctuations in insulin sensitivity, whereas it was absent in obese mice. The aforementioned diurnal rhythm oscillations were largely desynchronized by gut microbiota depletion, suggesting the indispensable role of gut microbiota in diurnal regulation of insulin sensitivity and bile acid metabolism. Consistently, 16S rRNA sequencing revealed that UDCA-associated bacteria exhibited diurnal rhythm oscillations that paralleled the fluctuation in insulin sensitivity. Collectively, the current study provides compelling evidence regarding the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis. Moreover, we have elucidated the deleterious effects of obesity on gut microbiome-bile acid metabolism in both the genetic obesity model and the diet-induced obesity model. |
WOS关键词 | ORAL GLUCOSE-TOLERANCE ; CIRCADIAN-RHYTHMS ; GROWTH-HORMONE ; PLASMA-INSULIN ; INTESTINAL MICROBIOTA ; URSODEOXYCHOLIC ACID ; BLOOD-GLUCOSE ; SECRETION ; CLOCK ; TIME |
资助项目 | National Key Research and Development Program of China[2021YFA1301200] ; National Key Research and Development Program of China[2019YFA0904500] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB39020600] ; National Natural Science Foundation of China[82222071] ; National Natural Science Foundation of China[82104253] ; National Natural Science Foundation of China[32222024] ; Shanghai Municipal Science and Technology Major Project |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:001113586400001 |
源URL | [http://119.78.100.183/handle/2S10ELR8/308110] |
专题 | 新药研究国家重点实验室 |
通讯作者 | Xu, Lingyan; Xie, Cen |
作者单位 | 1.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China 2.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Nanchang Univ, Sch Pharmaceut Sci, Nanchang, Peoples R China 5.China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 7.East China Normal Univ, Inst Biomed Sci, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Guo, Xiaozhen,Wang, Jiawen,Xu, Hualing,et al. Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2024,1869(1):13. |
APA | Guo, Xiaozhen.,Wang, Jiawen.,Xu, Hualing.,Wang, Yangyang.,Cao, Yutang.,...&Xie, Cen.(2024).Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1869(1),13. |
MLA | Guo, Xiaozhen,et al."Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1869.1(2024):13. |
入库方式: OAI收割
来源:上海药物研究所
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