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Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization

文献类型：期刊论文

作者Zhu, Yongcheng6; Liu, Yunyao6; Ma, Yuxiang5; Tan, Cheng1,2; He, Yuan6; Qiang, Lei1,6; Chen, Liu6; Huang, He4; Huang, Siting6; Zhang, Huiling6
刊名CELL REPORTS
出版日期2023-11-28
卷号42期号:11页码:24
ISSN号2211-1247
DOI10.1016/j.celrep.2023.113430
通讯作者Tan, Cheng(tancheng@yeah.net) ; He, Yuan(yuanhe0822@cpu.edu.cn) ; Qiang, Lei(lqiang@cpu.edu.cn) ; Huang, He(hhuang@simm.ac.cn)
英文摘要Macroautophagy/autophagy plays a pivotal role in immune regulation. Its significance is evident in modula-tion of immune cell differentiation and maturation, physiologically and pathologically. Here, we investigate the role of macrophage autophagy on the development of atopic dermatitis (AD). By employing an MC903-induced AD mice model, we observe reduced cutaneous inflammation in macrophage Atg5 cKO mice compared with WT mice. Notably, there is a decreased infiltration of M2 macrophages in lesional skin from Atg5 cKO mice. Furthermore, impaired STAT6 phosphorylation and diminished expression of M2 markers are detected in autophagy-deficient macrophages. Our mechanistic exploration reveals that CEBPB drives the transcription of SOCS1/3 and SQSTM1/p62-mediated autophagy degrades CEBPB normally. Autophagy deficiency leads to CEBPB accumulation, and further promotes the expression of SOCS1/3. This process in-hibits JAK1-STAT6 pathway activation and M2 marker expression. Together, our study indicates that auto-phagy is required for M2 activation and macrophage autophagy may be a promising target for AD intervention.
WOS关键词BINDING PROTEIN ; C/EBP-BETA ; CELLS ; DEGRADATION ; CHEMOKINE ; ACTIVATION ; CYTOKINES ; DEFENSE ; POPULATIONS ; PATHWAYS
资助项目National Natural Science Foundation of China[81974425] ; National Natural Science Foundation of China[82002907] ; Natural Science Foundation of Jiangsu Province[BK20211578] ; Natural Science Foundation of Jiangsu Province[BK20210419]
WOS研究方向Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:001112408700001
源URL[http://119.78.100.183/handle/2S10ELR8/308137]  
专题中国科学院上海药物研究所
通讯作者Tan, Cheng; He, Yuan; Qiang, Lei; Huang, He
作者单位1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing 210042, Peoples R China
2.Nanjing Univ Chinese Med, Affiliated Hosp, Dept Dermatol, 155 Hanzhong Rd, Nanjing 210029, Peoples R China
3.Univ Chicago, Dept Med, Sect Dermatol, Chicago, IL USA
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201213, Peoples R China
5.Guilin Med Univ, Dept Pharmacol, Guilin 541199, Peoples R China
6.China Pharmaceut Univ, Sch Basic Med & Clin Pharm, State Key Lab Nat Med, Nanjing 211198, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yongcheng,Liu, Yunyao,Ma, Yuxiang,et al. Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization[J]. CELL REPORTS,2023,42(11):24.
APA Zhu, Yongcheng.,Liu, Yunyao.,Ma, Yuxiang.,Tan, Cheng.,He, Yuan.,...&He, Yuying.(2023).Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.CELL REPORTS,42(11),24.
MLA Zhu, Yongcheng,et al."Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization".CELL REPORTS 42.11(2023):24.

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来源：上海药物研究所

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