Towards a comprehensive view of the herpes B virus
文献类型：期刊论文
| 作者 | Lu, Jiangling1,2,3; Long, Yiru2,3; Sun, Jianhua1,2,3 ; Gong, Likun1,2,3
|
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2023-11-16 |
| 卷号 | 14页码:16 |
| ISSN号 | 1664-3224 |
| 关键词 | herpes B virus zoonotic pathogens diagnosis therapy alpha-herpesvirus |
| DOI | 10.3389/fimmu.2023.1281384 |
| 通讯作者 | Sun, Jianhua(jhsun@cdser.simm.ac.cn) ; Gong, Likun(lkgong@simm.ac.cn) |
| 英文摘要 | Herpes B virus is a biosafety level 4 pathogen and widespread in its natural host species, macaques. Although most infected monkeys show asymptomatic or mild symptoms, human infections with this virus can cause serious neurological symptoms or fatal encephalomyelitis with a high mortality rate. Herpes B virus can be latent in the sensory ganglia of monkeys and humans, often leading to missed diagnoses. Furthermore, the herpes B virus has extensive antigen crossover with HSV, SA8, and HVP-2, causing false-positive results frequently. Timely diagnosis, along with methods with sensitivity and specificity, are urgent for research on the herpes B virus. The lack of a clear understanding of the host invasion and life cycle of the herpes B virus has led to slow progress in the development of effective vaccines and drugs. This review discusses the research progress and problems of the epidemiology of herpes B virus, detection methods and therapy, hoping to inspire further investigation into important factors associated with transmission of herpes B virus in macaques and humans, and arouse the development of effective vaccines or drugs, to promote the establishment of specific pathogen-free (SPF) monkeys and protect humans to effectively avoid herpes B virus infection. |
| WOS关键词 | CERCOPITHECINE HERPESVIRUS-1 GENOME ; RECEPTOR-RELATED PROTEIN-1 ; DOT-IMMUNOBINDING ASSAY ; CELL-CELL FUSION ; GLYCOPROTEIN-D ; MACACINE HERPESVIRUS-1 ; MONOCLONAL-ANTIBODIES ; GENETIC ARRANGEMENT ; ALPHA-HERPESVIRUSES ; CYNOMOLGUS MONKEYS |
| 资助项目 | Foundation of Shanghai Science and Technology Committee[22140900501] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:001110932000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308143]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Sun, Jianhua; Gong, Likun |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jiangling,Long, Yiru,Sun, Jianhua,et al. Towards a comprehensive view of the herpes B virus[J]. FRONTIERS IN IMMUNOLOGY,2023,14:16. |
| APA | Lu, Jiangling,Long, Yiru,Sun, Jianhua,&Gong, Likun.(2023).Towards a comprehensive view of the herpes B virus.FRONTIERS IN IMMUNOLOGY,14,16. |
| MLA | Lu, Jiangling,et al."Towards a comprehensive view of the herpes B virus".FRONTIERS IN IMMUNOLOGY 14(2023):16. |
入库方式： OAI收割
来源：上海药物研究所
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