Jin-Fu-An decoction manipulation of macrophage polarization via β-catenin (CTNNB1) synergizes with cisplatin in lung cancer
文献类型：期刊论文
| 作者 | Tang, Yang5,6,7; Sun, Zhe5,7; Wu, Siqi5,7; Zhang, Chengyu4,5; Zhang, Yanling3,7; Cao, Yang1,2,7 |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2023-12-01 |
| 卷号 | 168页码:17 |
| ISSN号 | 0753-3322 |
| 关键词 | Lung cancer Jin-Fu-An decoction Tumor-associated macrophages Macrophage polarization beta-catenin Infiltration of cytotoxic T cells |
| DOI | 10.1016/j.biopha.2023.115828 |
| 通讯作者 | Cao, Yang(Caoyang0324@gzucm.edu.cn) |
| 英文摘要 | Previous studies have demonstrated that tumor-associated macrophages (TAMs) exhibiting an M2 phenotype contribute significantly to the pathogenesis of various cancer types, including lung cancer. Therapeutic approaches targeting TAMs have the potential to complement and synergize with conventional chemotherapy and immunotherapy. Through database analysis, it has become evident that the expression of CTNNB1 (beta-catenin) is predominantly localized in macrophages, and its presence is associated with unfavorable outcomes in the absence of CD8+ cells. Jin-Fu-An decoction (JFAD) has been utilized as an adjunct to augment current clinical interventions. By conducting a network pharmacological analysis, we discovered that CTNNB1 is a significant target of JFAD. Experiments were conducted to examine the impact of JFAD on macrophage polarization both in vitro and in vivo. Furthermore, the study investigated the combined effect of JFAD and cisplatin (CDDP) on mitigating adverse reactions and prolonging survival in subcutaneously transplanted tumor models and orthotopic lung cancer models. The percentage of M1 and M2 macrophages in the tumor and spleen were measured using flow cytometry. Additionally, the levels of beta-catenin, M1, and M2 macrophage markers were measured by Western blotting and qPCR, while CD8 and iNOS protein expression was analyzed via immunohistochemistry. Our research findings indicate that JFAD has the ability to modulate the transformation of M2 macrophages into M1 macrophages, augment the anticancer efficacy of CDDP, and diminish the expression of cell-related markers in M2 cells. This regulatory effect may potentially be associated with the downregulation of beta-catenin expression. |
| WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; HEPATOCELLULAR-CARCINOMA ; ACTIVATION ; EXPRESSION ; MUTATIONS ; PROGNOSIS ; SURVIVAL ; PATHWAY ; POOR |
| 资助项目 | National Natural Science Foundation of China[81973815] ; National Natural Science Foundation of China[82174456] ; Guangzhou TCM and Integrated Traditional Chinese and Western Medicine Science and Technology Project[20222A011007] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:001110210400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308146]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cao, Yang |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Affiliated Hosp 1, 16 Jichang Rd, Guangzhou 510000, Peoples R China 2.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Guangzhou 510000, Peoples R China 3.Guangzhou Med Univ, Affiliated Hosp 4, Dept Oncol, Guangzhou 510000, Peoples R China 4.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510000, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China 6.Guangzhou Med Univ, Affiliated TCM Hosp, Dept Oncol, Guangzhou 510000, Peoples R China 7.Guangzhou Univ Chinese Med, Clin Sch 1, Guangzhou 510000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Yang,Sun, Zhe,Wu, Siqi,et al. Jin-Fu-An decoction manipulation of macrophage polarization via β-catenin (CTNNB1) synergizes with cisplatin in lung cancer[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,168:17. |
| APA | Tang, Yang,Sun, Zhe,Wu, Siqi,Zhang, Chengyu,Zhang, Yanling,&Cao, Yang.(2023).Jin-Fu-An decoction manipulation of macrophage polarization via β-catenin (CTNNB1) synergizes with cisplatin in lung cancer.BIOMEDICINE & PHARMACOTHERAPY,168,17. |
| MLA | Tang, Yang,et al."Jin-Fu-An decoction manipulation of macrophage polarization via β-catenin (CTNNB1) synergizes with cisplatin in lung cancer".BIOMEDICINE & PHARMACOTHERAPY 168(2023):17. |
入库方式： OAI收割
来源：上海药物研究所
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