Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol
文献类型：期刊论文
| 作者 | Huang, Changying2,3; Peng, Liyang3; Xu, Xinqi3; Lu, Yunshu3; Wang, Xueting3; Lan, Zhongming1; Chen, Jingdi3; Zhou, Yanxia3 |
| 刊名 | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
 |
| 出版日期 | 2023-11-01 |
| 卷号 | 89页码:12 |
| 关键词 | In situ gels Chloramphenicol Nanoparticles Drug release Antimicrobial activity |
| ISSN号 | 1773-2247 |
| DOI | 10.1016/j.jddst.2023.104962 |
| 通讯作者 | Zhou, Yanxia(zhouyx@sdu.edu.cn) |
| 英文摘要 | To enhance the antimicrobial activity of chloramphenicol (CAP) and extend ocular retention, chitosan nano-particles carrying chloramphenicol (CAP-CNPs) were prepared by ionotropic gelation technique and further incorporated into thermosensitive in situ gel (CAP-CNPs-Gel). The formulation of the thermosensitive gel was optimized using a central composite design-response surface methodology (CCD-RSM). The optimized CAP-CNPs-Gel was selected to investigate its drug release kinetics, antimicrobial activity, and ocular irritancy. The average particle size and zeta potential of the optimized CAP-CNPs were 137.5 +/- 3.6 nm and 29.9 +/- 0.3 mV, respectively. The gel matrix was found to be most effective with a combination of 20.5% (w/v) poloxamer 407 and 5.0% (w/v) poloxamer 188. The CAP-CNPs-Gel formulation demonstrated sustained drug release properties, with drug release lasting up to 18 h. Furthermore, CAP-CNPs-Gel exhibited superior antibacterial activity when compared to both CAP eye drops and CAP gel. Through in vivo studies, CAP-CNPs-Gel was shown to be well tolerated by the eyes and capable of prolonging precorneal retention time for up to 40 min. These promising results suggest that CAP-CNPs-Gel has the potential to serve as a reliable treatment for eye infections. Moreover, the thermosensitive nanoparticulate gelling system utilized in this study provides a valuable carrier for effective CAP delivery. |
| WOS关键词 | IONOTROPIC GELATION ; VITRO ; HYDROGEL ; SYSTEMS ; VIVO ; PHARMACODYNAMICS ; OPTIMIZATION ; TOOL ; RSM |
| 资助项目 | National Natural Science Founda-tion of China[31700116] ; Natural Science Foundation of Shandong Province[ZR2023MD103] ; China Postdoctoral Science Foundation[2017M62218] ; Key Science and Technology Program of Weihai |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001108515700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308161]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Yanxia |
| 作者单位 | 1.Shandong Univ, Sch Business, Weihai 264209, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Shandong Univ, Marine Coll, Weihai 264209, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Changying,Peng, Liyang,Xu, Xinqi,et al. Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2023,89:12. |
| APA | Huang, Changying.,Peng, Liyang.,Xu, Xinqi.,Lu, Yunshu.,Wang, Xueting.,...&Zhou, Yanxia.(2023).Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,89,12. |
| MLA | Huang, Changying,et al."Preparation and characteristics of a thermosensitive in situ gel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 89(2023):12. |
入库方式： OAI收割
来源：上海药物研究所
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