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Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance

文献类型：期刊论文

作者Xia, Jiaxuan5,6; Chen, Chen5,6; Dong, Meichen5,6; Zhu, Ying2; Wang, Anni5,6; Li, Shiyi5,6; Zhang, Ru5,6; Feng, Chunbo1; Jiang, Xinnan1; Xu, Xinchun3
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2023-12-01
卷号364页码:23-36
ISSN号0168-3659
关键词Ginsenoside Rg3 Liposomes Polyethylene glycol Long circulation Accelerated blood clearance (ABC) IgM antibody Complement activation
DOI10.1016/j.jconrel.2023.10.023
通讯作者Xu, Xinchun(xuxinchun@live.cn) ; Wang, Jianxin(jxwang@fudan.edu.cn)
英文摘要PEGylated cholesterol-containing liposomes (Chol-PEG-lipo) have been widely used as a drug carrier for their good stealth property in blood circulation where cholesterol maintains the stability of the liposomal lipid bilayer and PEGylation endows liposomes with long circulation capability. However, cholesterol-related disadvantages and the accelerated blood clearance (ABC) phenomenon caused by PEGylation greatly limit the application of conventional stealth liposomes in clinic. Herein, ginsenoside Rg3 was selected to substitute cholesterol and PEG for liposomes preparation (Rg3-lipo). Rg3 was proved with similar liposomal membrane regulation ability to cholesterol and comparable long circulation effect to PEG. In addition, repeated administrations of Chol-PEG-lipo and Rg3-lipo were performed. The circulation time of the second dose of Chol-PEG-lipo was substantially reduced accompanied by a greatly increased accumulation in the liver due to the induction of anti-PEG IgM and the subsequent activated complement system. In contrast, no significantly increased level of relative plasma cells, IgM secretion and the complement activation in blood circulation was observed after the second injection of Rg3lipo. As a result, Rg3-lipo showed great stealth property without ABC phenomenon. Therefore, developing liposomes utilizing Rg3 instead of PEG and cholesterol presents a promising strategy to prolong the blood circulation time of liposomes without triggering the ABC phenomenon and activated immune responses.
WOS关键词PEGYLATED LIPOSOMES ; COMPLEMENT ACTIVATION ; REPEATED INJECTIONS ; PLASMA-PROTEINS ; ABC PHENOMENON ; CHOLESTEROL ; BIODISTRIBUTION ; NANOPARTICLE ; IGM ; PHARMACOKINETICS
资助项目National Natural Science Foundation of China[82074277] ; National Natural Science Foundation of China[81773911] ; Development Project of Shanghai Peak Disciplines-Integrated Medicine[20180101]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:001105742300001
源URL[http://119.78.100.183/handle/2S10ELR8/308173]  
专题中国科学院上海药物研究所
通讯作者Xu, Xinchun; Wang, Jianxin
作者单位1.Shanghai Jahwa United Co Ltd, R&D Ctr, Shanghai 200082, Peoples R China
2.Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai 200032, Peoples R China
3.Fudan Univ, Shanghai Xuhui Cent Hosp, Xuhui Hosp, Shanghai 200031, Peoples R China
4.Fudan Univ, Inst Mat Med, Acad Chinese & Western Integrat Med, Shanghai 201203, Peoples R China
5.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China
6.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Xia, Jiaxuan,Chen, Chen,Dong, Meichen,et al. Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance[J]. JOURNAL OF CONTROLLED RELEASE,2023,364:23-36.
APA Xia, Jiaxuan.,Chen, Chen.,Dong, Meichen.,Zhu, Ying.,Wang, Anni.,...&Wang, Jianxin.(2023).Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance.JOURNAL OF CONTROLLED RELEASE,364,23-36.
MLA Xia, Jiaxuan,et al."Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance".JOURNAL OF CONTROLLED RELEASE 364(2023):23-36.

入库方式： OAI收割

来源：上海药物研究所

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