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Rational design of oral delivery nanosystems for hypoglycemic peptides

文献类型：期刊论文

作者Peng, Taoxing3,4,5; Shao, Xinyue4; Long, Li4; Liu, Han4; Song, Wenqin4; Hou, Jiazhen4; Zhong, Haijun3; Ding, Yang5; Huang, Yongzhuo1,2,4
刊名NANO TODAY
出版日期2023-12-01
卷号53页码:19
ISSN号1748-0132
关键词Hypoglycemic peptides Oral delivery Mucus penetration Endocytosis Intracellular trafficking Exocytosis
DOI10.1016/j.nantod.2023.102031
通讯作者Zhong, Haijun(zhonghj@ncu.edu.cn) ; Ding, Yang(dydszyzf@163.com) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Hypoglycemic peptides have exhibited great clinical benefits for diabetics and body weight control due to their high activity, high specificity, and low toxicity. However, frequent subcutaneous injection of hypoglycemic peptides is likely to trigger infections and adverse reactions. Oral administration is an ideal route for hypoglycemic peptides, but confronting a formidable challenge of poor oral bioavailability. The promising solution to solving this problem is to use nano drug delivery systems (NDDS). There are a series of biological barriers against effective delivery of peptide drugs including the mucus and epithelial barriers, which must be considered for rational design of oral NDDS. In this review, the therapeutic application of hypoglycemic peptides is introduced and the barriers restricting the delivery efficiency of oral NDDS are analyzed and discussed. We propose a six step AMEIEB delivery cascade as a guideline for designing efficient oral NDDS of hypoglycemic peptides. And some specific considerations of how to improve delivery efficiency at each barrier are highlighted. The advances for overcoming these barriers and the recent delivery strategies are summarized.
WOS关键词GLUCAGON-LIKE PEPTIDE-1 ; INTESTINAL PERMEATION ENHANCERS ; SOLID LIPID NANOPARTICLES ; LIGAND-MODIFIED NANOPARTICLES ; CELL-PENETRATING PEPTIDES ; DRUG-DELIVERY ; GOLD NANOPARTICLES ; IN-VITRO ; MUCOPENETRATING NANOPARTICLES ; CHITOSAN DERIVATIVES
资助项目National Key Research and Development Program of China[2021YFE0103100] ; National Key Research and Development Program of China[2021YFC2400600] ; NFSC[81925035] ; Natural Science Foundation of Jiangxi Province[20202BAB206083] ; High-level Innovative Research Institute[LJ2021001] ; Department of Science and Technology of Guangdong Province ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; Zhongshan Municipal Bureau of Science and Technology[2019B090904008] ; High-level New RD Institute ; [2021B0909050003]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:001104145600001
源URL[http://119.78.100.183/handle/2S10ELR8/308185]  
专题新药研究国家重点实验室
通讯作者Zhong, Haijun; Ding, Yang; Huang, Yongzhuo
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
2.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
3.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
5.China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Peng, Taoxing,Shao, Xinyue,Long, Li,et al. Rational design of oral delivery nanosystems for hypoglycemic peptides[J]. NANO TODAY,2023,53:19.
APA Peng, Taoxing.,Shao, Xinyue.,Long, Li.,Liu, Han.,Song, Wenqin.,...&Huang, Yongzhuo.(2023).Rational design of oral delivery nanosystems for hypoglycemic peptides.NANO TODAY,53,19.
MLA Peng, Taoxing,et al."Rational design of oral delivery nanosystems for hypoglycemic peptides".NANO TODAY 53(2023):19.

入库方式： OAI收割

来源：上海药物研究所

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