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Novel NIR-II fluorescent probes for biliary atresia imaging

文献类型：期刊论文

作者Zeng, Xiaodong1,3,8; Liao, Yuqin5,6,7,8; Qiao, Xue4,8; Liang, Ke3,8; Luo, Qiusi5,6,7,8; Deng, Mingbo5,6,7,8; Liu, Yishen5,6,7,8; Zhang, Weijing2,5,6,7; Hong, Xuechuan3,4,8; Xiao, Yuling5,6,7,8
刊名ACTA PHARMACEUTICA SINICA B
出版日期2023-11-01
卷号13期号:11页码:4578-4590
ISSN号2211-3835
关键词Biliary atresia Fluorescence imaging Second near-infrared window Early diagnosis Hepatobiliary excretion
DOI10.1016/j.apsb.2023.07.005
通讯作者Xiao, Yuling(xiaoyl@whu.edu.cn)
英文摘要Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is very important to develop a simple, safe and reliable method for the early diagnosis of biliary atresia. Herein, a novel NIR-II fluorescence probe, HZL2, with high quantum yield, excellent biocompatibility, low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability. A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time, allowing for an early diagnosis of the disease. This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia.
WOS关键词FLUOROPHORES ; PATHOGENESIS ; THERAPY ; DOTS
资助项目Guang-dong Basic and Applied Basic Research Foundation[XZ202201ZY0046G] ; Shenzhen Science and Technology Research Grant[2023A1515012649] ; Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University[JCYJ20220530140605012] ; China Postdoctoral Science Foundation[ZNJC202209] ; Fundamental Research Funds for the Central Universities[2022M712091]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号WOS:001108149000001
源URL[http://119.78.100.183/handle/2S10ELR8/308191]  
专题新药研究国家重点实验室
通讯作者Xiao, Yuling
作者单位1.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China
2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
3.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China
4.Tibet Univ, Sch Ecol & Environm, Key Lab Biodivers & Environm Qinghai Tibetan Plate, Minist Educ, Lhasa 850000, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Cardiol,State Key Lab Virol, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Zeng, Xiaodong,Liao, Yuqin,Qiao, Xue,et al. Novel NIR-II fluorescent probes for biliary atresia imaging[J]. ACTA PHARMACEUTICA SINICA B,2023,13(11):4578-4590.
APA Zeng, Xiaodong.,Liao, Yuqin.,Qiao, Xue.,Liang, Ke.,Luo, Qiusi.,...&Xiao, Yuling.(2023).Novel NIR-II fluorescent probes for biliary atresia imaging.ACTA PHARMACEUTICA SINICA B,13(11),4578-4590.
MLA Zeng, Xiaodong,et al."Novel NIR-II fluorescent probes for biliary atresia imaging".ACTA PHARMACEUTICA SINICA B 13.11(2023):4578-4590.

入库方式： OAI收割

来源：上海药物研究所

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