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The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption

文献类型：期刊论文

作者Ding, Weihua11; Yang, Liuyue11; Shi, Eleanor11; Kim, Bowon11; Low, Sarah11; Hu, Kun10; Gao, Lei11; Chen, Ping9; Ding, Wei9; Borsook, David8
刊名NATURE COMMUNICATIONS
出版日期2023-10-25
卷号14期号:1页码:13
DOI10.1038/s41467-023-42283-6
通讯作者Feng, Guoping(fengg@mit.edu) ; Shen, Shiqian(sshen2@mgh.harvard.edu)
英文摘要Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing, attention/arousal and sleep spindle generation. We report that the TRN played an important role in CSD-induced hyperalgesia in mice, through its projections to the ventroposterior region of the thalamus. Metabolomics revealed that the level of N-arachidonoyl dopamine (NADA), an endocannabinoid, was decreased in the TRN after CSD. Using a recently developed CB1 receptor (cannabinoid receptor 1) activity sensor with spatiotemporal resolution, CB1 receptor activity in the TRN was found to be decreased after CSD. Moreover, CSD-induced hyperalgesia was attenuated by local NADA administration to the TRN. Taken together, these results suggest that TRN NADA signaling is critical for CSD-induced hyperalgesia. Generalized body pain and headaches are common experience after sleep disruption. How does sleep disruption lead to generalized pain is unknown. Here, authors reveal that N-arachidonoyl dopamine, an endocannabinoid, is critically implicated in pain perception after sleep disruption.
WOS关键词THALAMIC RETICULAR NUCLEUS ; PAIN ; NEURONS ; SENSITIVITY ; INSOMNIA ; ACCUMULATION ; RESTRICTION ; DEPRIVATION ; CONNECTIONS ; HOMEOSTASIS
资助项目The authors acknowledge MGH IACUC and the animal facility for their kind support; Scot Mackeil from MGH Bioengineer Lab for anesthesia equipment maintenance and validation; Department of Anesthesia, Critical Care and Pain Medicine of MGH for generous suppo ; MGH IACUC ; MGH Bioengineer Lab for anesthesia equipment maintenance and validation ; Department of Anesthesia, Critical Care and Pain Medicine of MGH[R61 NS126029] ; NIH[2334666] ; NSF EAGER
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:001096436800011
源URL[http://119.78.100.183/handle/2S10ELR8/308194]  
专题中国科学院上海药物研究所
通讯作者Feng, Guoping; Shen, Shiqian
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Shanghai, Peoples R China
2.MIT, Dept Brain & Cognit Sci, Cambridge, MA USA
3.MIT, McGovern Inst Brain Res, Cambridge, MA USA
4.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA USA
5.Harvard Med Sch, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Dept Radiol, Boston, MA USA
6.Korea Inst Sci & Technol, Ctr Neurosci, Seoul, South Korea
7.Brandeis Univ, Massachusetts Gen Hosp, Summer Intern Program, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA
8.Harvard Med Sch, Dept Radiol, Massachusetts Gen Hosp, Boston, MA USA
9.Univ Massachusetts Boston, Coll Sci & Math, Boston, MA USA
10.Tuft Univ, Dept Pathol, Sch Med, Boston, MA USA
推荐引用方式
GB/T 7714		 Ding, Weihua,Yang, Liuyue,Shi, Eleanor,et al. The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption[J]. NATURE COMMUNICATIONS,2023,14(1):13.
APA Ding, Weihua.,Yang, Liuyue.,Shi, Eleanor.,Kim, Bowon.,Low, Sarah.,...&Shen, Shiqian.(2023).The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption.NATURE COMMUNICATIONS,14(1),13.
MLA Ding, Weihua,et al."The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption".NATURE COMMUNICATIONS 14.1(2023):13.

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来源：上海药物研究所

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