Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna
文献类型：期刊论文
| 作者 | Huang, Yang1; Yao, Hongye1; Li, Xuehua1; Li, Fei2,3 ; Wang, Xiaoqing3,4; Fu, Zhiqiang1; Li, Ningjing1; Chen, Jingwen1
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| 刊名 | SSRN
 |
| 出版日期 | 2023 |
| ISSN号 | 15565068 |
| 关键词 | Detoxification Metabolism Nanostructured materials Proteins Toxicity Transcription |
| DOI | 10.2139/ssrn.4327486 |
| 英文摘要 | Graphene can be modified with functional groups when released into the environment. However, very little is known about molecular mechanisms of chronic aquatic toxicity induced by graphene nanomaterials with different surface functional groups. By using RNA sequencing, we investigated the toxic mechanisms of unfunctionalized graphene (u-G), carboxylated graphene (G-COOH), aminated graphene (G-NH2), hydroxylated graphene (G-OH) and thiolated graphene (G-SH) to Daphnia magna during 21-day exposure. We revealed that alteration of ferritin transcription levels in the "mineral absorption" signaling pathway is a molecular initiating event leading to potential of oxidative stress in Daphnia magna by u-G, while toxic effects of four functionalized graphenes are related to several metabolic pathways including the "protein digestion and absorption" pathway and "carbohydrate digestion and absorption" pathway. The transcription and translation related pathways were inhibited by G-NH2 and G-OH, which further affected the functions of proteins and normal life activities. Noticeably, detoxifications of graphene and its surface functional derivatives were promoted by increasing the gene expressions related to chitin and glucose metabolism as well as cuticle structure components. These findings demonstrate important mechanistic insights that can potentially be employed for safety assessment of graphene nanomaterials. © 2023, The Authors. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/34289]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_近岸生态与环境实验室 |
| 作者单位 | 1.Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Linggong Road 2, Dalian; 116024, China; 2.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao; 266071, China; 3.CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai; 264003, China; 4.University of Chinese Academy of Sciences, Beijing; 100049, China |
| 推荐引用方式 GB/T 7714 | Huang, Yang,Yao, Hongye,Li, Xuehua,et al. Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna[J]. SSRN,2023. |
| APA | Huang, Yang.,Yao, Hongye.,Li, Xuehua.,Li, Fei.,Wang, Xiaoqing.,...&Chen, Jingwen.(2023).Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna.SSRN. |
| MLA | Huang, Yang,et al."Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna".SSRN (2023). |
入库方式： OAI收割
来源：烟台海岸带研究所
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