Advances in biosynthesis of peptide drugs: Technology and industrialization
文献类型：期刊论文
| 作者 | Wang, Jing1,6; Chen, Long5; Qin, Song1 ; Xie, Mingyuan4; Luo, Shi-Zhong2,5; Li, Wenjun1,3
|
| 刊名 | BIOTECHNOLOGY JOURNAL
 |
| 出版日期 | 2023-11-14 |
| 页码 | 13 |
| ISSN号 | 1860-6768 |
| 关键词 | biosynthesis technology industrialization peptide drugs peptide synthesis |
| DOI | 10.1002/biot.202300256 |
| 通讯作者 | Luo, Shi-Zhong(luosz@mail.buct.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn) |
| 英文摘要 | Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. They have advantages of strong target specificity, high efficacy and low toxicity, thus showing great promise in the treatment of many diseases such as cancer, infections, and diabetes. Although an increasing number of peptide drugs have entered market in recent years, the preparation of peptide drug substances is yet a bottleneck problem for their industrial production. Comparing to the chemical synthesis method, peptide biosynthesis has advantages of simple synthesis, low cost, and low contamination. Therefore, the biosynthesis technology of peptide drugs has been widely used for manufacturing. Herein, we reviewed the development of peptide drugs and recent advances in peptide biosynthesis technology, in order to shed a light to the prospect of industrial production of peptide drugs based on biosynthesis technology. Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. Currently, with the development of biotechnology, the development and marketing of peptide drugs are showing a steady increasing trend. Recombinant peptide drugs have been widely used in medical applications such as diabetes, cancer, osteoporosis, multiple sclerosis, and hepatitis. Herein, we reviewed the development of peptide drugs and recent advances in peptide biosynthesis technology, in order to shed a light to the prospect of industrial production of peptide drugs based on biosynthesis technology.image |
| WOS关键词 | HALF-LIFE ; INSULIN ; ALLOPHYCOCYANIN ; STABILITY ; SEQUENCE ; VACCINE ; DESIGN ; CANCER ; ENZYME ; LIGAND |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001101802300001 |
| 资助机构 | This work was supported by The National Key Research and Development Program of China (2021YFC2103900), Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast (Grant numbers: ZDKC-2022-04) and High tech industrialization spec ; National Key Research and Development Program of China ; , Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast ; High tech industrialization special project in cooperation between Jilin Province ; Chinese Academy of Sciences |
| 源URL | [http://ir.yic.ac.cn/handle/133337/33225]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Luo, Shi-Zhong; Li, Wenjun |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China 2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 4.Sun Yat Sen Univ, Sch Phys, State Key Lab Optoelect Mat & Technol, Guangzhou, Peoples R China 5.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing, Peoples R China 6.Binzhou Med Univ, Coll Pharm, Yantai, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Chen, Long,Qin, Song,et al. Advances in biosynthesis of peptide drugs: Technology and industrialization[J]. BIOTECHNOLOGY JOURNAL,2023:13. |
| APA | Wang, Jing,Chen, Long,Qin, Song,Xie, Mingyuan,Luo, Shi-Zhong,&Li, Wenjun.(2023).Advances in biosynthesis of peptide drugs: Technology and industrialization.BIOTECHNOLOGY JOURNAL,13. |
| MLA | Wang, Jing,et al."Advances in biosynthesis of peptide drugs: Technology and industrialization".BIOTECHNOLOGY JOURNAL (2023):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。