Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress
文献类型：期刊论文
| 作者 | Li, Chong2; Jiao, Yukun1; Shen, Shumin3; Zhao, Wenchang4; Zhang, Qian3; Zhang, Shaojie4 |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2023-12-31 |
| 卷号 | 169页码:9 |
| ISSN号 | 0753-3322 |
| 关键词 | Chaenomeles sinensis Thouin Koeh Polysaccharide Carboxymethylation Ulcerative colitis Inflammation Oxidative stress |
| DOI | 10.1016/j.biopha.2023.115941 |
| 通讯作者 | Zhang, Qian(zhangqian1990122@163.com) ; Zhang, Shaojie(ZhangSJ_Polymers@163.com) |
| 英文摘要 | Chaenomeles sinensis fruit polysaccharide (CSP) and carboxymethylated CSP (CSP-M) were prepared using ultrasound extraction and the sodium hydroxide-chloroacetic acid method. Structural analysis revealed that both CSP and CSP-M mainly consisted of glucose, arabinose, rhamnose, glucuronic acid, galactose, and xylose, and the introduction of carboxymethyl did not damage the polymer chain of CSP. In vivo studies verified that both CSP and CSP-M could remarkably alleviate the symptoms of ulcerative colitis (UC) mice and reduce intestinal epithelial cell depletion, along with the infiltration of inflammatory cells in colon tissue, by mediating the expression of myeloperoxidase (MPO), inflammatory factors [tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6], and oxidative stress factors [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and nitric oxide (NO)]. Most importantly, the introduction of carboxymethyl significantly enhanced the anti-UC activity of CSP, confirming the efficacy of carboxymethylation as a method to enhance the biological activities of CSP, thereby suggesting the potential of CSP-M as a therapeutic option for UC. |
| WOS关键词 | ANTIOXIDANT ACTIVITIES ; BOWEL-DISEASE ; EXTRACT ; MICE |
| 资助项目 | Guangzhou Basic and Applied Basic Research Foundation[B2023411] ; [2023A04J1154] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:001127372900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308281]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Qian; Zhang, Shaojie |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 3.Guangdong Pharmaceut Univ, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Sch Pharm, Guangdong Prov Key Lab Adv Drug Delivery, Guangzhou 510006, Peoples R China 4.Guangdong Prov Key Lab Res & Dev Nat Drugs, Dongguan Key Lab TCM Prevent & Treatment Digest Di, Dongguan Key Lab Screening & Res Antiinflammatory, Guangdong Med Univ, Dongguan 523808, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chong,Jiao, Yukun,Shen, Shumin,et al. Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,169:9. |
| APA | Li, Chong,Jiao, Yukun,Shen, Shumin,Zhao, Wenchang,Zhang, Qian,&Zhang, Shaojie.(2023).Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress.BIOMEDICINE & PHARMACOTHERAPY,169,9. |
| MLA | Li, Chong,et al."Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress".BIOMEDICINE & PHARMACOTHERAPY 169(2023):9. |
入库方式： OAI收割
来源：上海药物研究所
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