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Species discrimination of multiple botanical origins of Fritillaria species based on infrared spectroscopy, thin layer chromatography-image analysis and untargeted metabolomics

文献类型：期刊论文

作者An, Ya-Ling2,3; Li, Yun3; Wei, Wen-Long3; Li, Zhen-Wei3; Zhang, Jian-Qing3; Yao, Chang-Liang3; Li, Jia-Yuan3; Bi, Qi-Rui3; Qu, Hua3; Pan, Huiqin1
刊名PHYTOMEDICINE
出版日期2024
卷号123页码:11
关键词Species discrimination Fritillaria species Infrared spectroscopy Thin layer chromatography-image analysis Untargeted metabolomics
ISSN号0944-7113
DOI10.1016/j.phymed.2023.155228
通讯作者Guo, De-An(daguo@simm.ac.cn)
英文摘要Background: Fritillaria Bulbus (FB), a precious medicinal herb renowned for its heat-clearing, lung-moistening, cough-relieving and phlegm-eliminating effects. In pursuit of profits, unscrupulous merchants have engaged in the substitution or adulteration of valuable varieties with cheaper alternatives. It is, therefore, urgent to develop effective technical approaches to identify FBs from adulterants. Methods: This paper employed infrared spectroscopy (IR), thin layer chromatography-image analysis (TLC-IA), and untargeted metabolomics techniques to discriminate ten species of FBs. Results: Five species of FBs were successfully differentiated using mid-infrared spectroscopy. Furthermore, the power of TLC-IA technology allowed the differentiation of five species of FBs and two origins of FCBs (Fritillariae Cirrhosae Bulbus). Remarkably, through the application of untargeted metabolomics technique, the precise discrimination of five species of FBs, as well as three origins of FCBs were accomplished. Moreover, a comprehensive identification of 101 markers that reliably distinguished diverse FBs was achieved through the employment of untargeted metabolomics technique. Conclusion: The investigation presented powerful means of detection for assuring the quality control of Fritillaria herbs.
WOS关键词IDENTIFICATION ; ALKALOIDS ; BULBUS ; EXPECTORANT ; LILIACEAE ; STRATEGY ; SAFFRON ; BARCODE
资助项目Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine ; National Natural Science Foundation of China[82130111] ; Xinjiang Uygur Autonomous Region Institute for Food and Drug Control, Hubei Institute for Food and Drug Control, Shenzhen Institute for Food and Drug Control, Chongqing Institute for Food and Drug Control and Gansu Institute for Food and Drug Control
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:001125561500001
出版者ELSEVIER GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/308290]  
专题中国科学院上海药物研究所
通讯作者Guo, De-An
作者单位1.Shanghai Inst Food & Drug Control, Zhangheng RD1500, Shanghai 201112, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 An, Ya-Ling,Li, Yun,Wei, Wen-Long,et al. Species discrimination of multiple botanical origins of Fritillaria species based on infrared spectroscopy, thin layer chromatography-image analysis and untargeted metabolomics[J]. PHYTOMEDICINE,2024,123:11.
APA An, Ya-Ling.,Li, Yun.,Wei, Wen-Long.,Li, Zhen-Wei.,Zhang, Jian-Qing.,...&Guo, De-An.(2024).Species discrimination of multiple botanical origins of Fritillaria species based on infrared spectroscopy, thin layer chromatography-image analysis and untargeted metabolomics.PHYTOMEDICINE,123,11.
MLA An, Ya-Ling,et al."Species discrimination of multiple botanical origins of Fritillaria species based on infrared spectroscopy, thin layer chromatography-image analysis and untargeted metabolomics".PHYTOMEDICINE 123(2024):11.

入库方式： OAI收割

来源：上海药物研究所

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