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Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

文献类型：期刊论文

作者Wu, Yueci7; Sun, Lu-Lu4,5; Han, Hai-Hao4,5; He, Xiao-Peng2,3; Cao, Weiguo6; James, Tony D.1,7
刊名CHEMICAL SCIENCE
出版日期2024-01-03
卷号15期号:2页码:757-764
ISSN号2041-6520
DOI10.1039/d3sc05010f
通讯作者Han, Hai-Hao(hanhaihao@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Cao, Weiguo(wgcao@shu.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk)
英文摘要Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO-) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO- in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO- with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO- in live cells and endogenous ONOO- in APAP-induced liver injury of HepG2 cells. Ratiometric FRET-based probe CD-N-I was developed to detect exogenous ONOO- in live cells and endogenous ONOO- in APAP-induced liver injury of HepG2 cells.
WOS关键词ACETAMINOPHEN-INDUCED HEPATOTOXICITY ; GRAPHENE QUANTUM DOTS ; FLUORESCENT-PROBES ; ELECTROCHEMICAL DETECTION ; IN-VIVO ; EMISSION ; 3-NITROTYROSINE ; BIOCHEMISTRY ; TYROSINE ; CELLS
资助项目China Scholarship Council ; China Scholarship Council ; University of Bath and Shanghai University ; University of Bath[2020ZD01] ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[21788102] ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[91853201] ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[9185920077] ; National Natural Science Foundation of China[2023JCYJ059] ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[SYS202205] ; Shandong Laboratory Program
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:001125522000001
源URL[http://119.78.100.183/handle/2S10ELR8/308298]  
专题中国科学院上海药物研究所
通讯作者Han, Hai-Hao; He, Xiao-Peng; Cao, Weiguo; James, Tony D.
作者单位1.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
2.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
3.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem,Key Lab Adv, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
6.Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
7.Univ Bath, Dept Chem, Bath BA2 7AY, England
推荐引用方式
GB/T 7714		 Wu, Yueci,Sun, Lu-Lu,Han, Hai-Hao,et al. Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury[J]. CHEMICAL SCIENCE,2024,15(2):757-764.
APA Wu, Yueci,Sun, Lu-Lu,Han, Hai-Hao,He, Xiao-Peng,Cao, Weiguo,&James, Tony D..(2024).Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury.CHEMICAL SCIENCE,15(2),757-764.
MLA Wu, Yueci,et al."Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury".CHEMICAL SCIENCE 15.2(2024):757-764.

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来源：上海药物研究所

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