Asponchimides A-E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis
文献类型：期刊论文
| 作者 | Nie, Jinchun1,2; Mei, Fang1; Zheng, Yueyuan1; Wen, Qiuyi1; Li, Zhenwei1; Zhang, Daidi1; Li, Wei1,2; Guo, Dean1,2
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2023-11-01 |
| 卷号 | 21期号:11页码:859-867 |
| ISSN号 | 2095-6975 |
| 关键词 | Aspongopus chinensis N-acetyldopamine trimer ECD calculations NO inhibitory activity |
| DOI | 10.1016/S1875-5364(23)60483-2 |
| 通讯作者 | Li, Wei(liwei1@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn) |
| 英文摘要 | Five new racemic N-acetyldopamine (NADA) trimers, asponchimides A-E (1-5), were isolated from Aspongopus chinensis, a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1-5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)-and (-)-asponchimides A-E (1a/1b-5a/5b). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) cal-culations. Compounds 1-5 are pioneering instances of NADA trimers featuring a Delta 7 double bond. When subjected to a series of bioas-says, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells. |
| WOS关键词 | INSECTS ; ARTHROPODS |
| 资助项目 | Key Program of National Natural Science Foundation of China[82130111] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] ; High-level New R&D Institute of Department of Science and Tech-nology of Guangdong Province[2019B090904008] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| WOS记录号 | WOS:001128017500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/308350]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Wei; Guo, Dean |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Jinchun,Mei, Fang,Zheng, Yueyuan,et al. Asponchimides A-E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2023,21(11):859-867. |
| APA | Nie, Jinchun.,Mei, Fang.,Zheng, Yueyuan.,Wen, Qiuyi.,Li, Zhenwei.,...&Guo, Dean.(2023).Asponchimides A-E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis.CHINESE JOURNAL OF NATURAL MEDICINES,21(11),859-867. |
| MLA | Nie, Jinchun,et al."Asponchimides A-E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis".CHINESE JOURNAL OF NATURAL MEDICINES 21.11(2023):859-867. |
入库方式： OAI收割
来源：上海药物研究所
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