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Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians

文献类型：期刊论文

作者Zhang, Tianyu2,3,4; Wang, Xin2,3,4; Zhang, Qianqian3,4; Yang, Dinglong3,4; Zhang, Xiaoli3,4; Liu, Hui3,4; Dong, Zhijun3,4; Zhao, Jianmin1,3,4
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2024-02-20
卷号912页码:14
关键词Antibiotics residues Ocean acidification Physiological response Metabolomics Bay scallop
ISSN号0048-9697
DOI10.1016/j.scitotenv.2023.168941
通讯作者Zhao, Jianmin(jmzhao@yic.ac.cn)
英文摘要Coastal areas are confronted with compounding threats arising from both climatic and non-climatic stressors. Antibiotic pollution and ocean acidification are two prevalently concurrent environmental stressors. Yet their interactive effects on marine biota have not been investigated adequately and the compound hazard remain obscure. In this study, bay scallops Argopecten irradians irradians were exposed to multiple antibiotics (sulfamethoxazole, tetracycline, oxytetracycline, norfloxacin, and erythromycin, each at a concentration of 1 mu g/L) combined with/without acidic seawater (pH 7.6) for 35 days. The single and interactive effects of the two stressors on A. irradians irradians were determined from multidimensional bio-responses, including energetic physiological traits as well as the molecular underpinning (metabolome and expressions of key genes). Results showed that multiple antibiotics predominantly enhanced the process of DNA repair and replication via disturbing the purine metabolism pathway. This alternation is perhaps to cope with the DNA damage induced by oxidative stress. Ocean acidification mainly disrupted energy metabolism and ammonia metabolism of the scallops, as evidenced by the increased ammonia excretion rate, the decreased O:N ratio, and perturbations in amino acid metabolism pathways. Moreover, the antagonistic effects of multiple antibiotics and ocean acidification caused alternations in the relative abundance of neurotransmitter and gene expression of neurotransmitter receptors, which may lead to neurological disorders in scallops. Overall, the revealed alternations in physiological traits, metabolites and gene expressions provide insightful information for the health status of bivalves in a natural environmental condition under the climate change scenarios.
WOS关键词OXIDATIVE STRESS ; SEASONAL-VARIATION ; RESISTANCE GENES ; COASTAL WATER ; DNA ; MUSSELS ; RESPONSES ; TOXICITY ; ACID ; SEA
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001133719600001
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science & Technology Fundamental Resources Investigation Program of China ; Seed Project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences
源URL[http://ir.yic.ac.cn/handle/133337/34362]  
专题海岸带生物学与生物资源利用重点实验室
中国科学院牟平海岸带环境综合试验站
海岸带生物资源高效利用研究与发展中心
通讯作者Zhao, Jianmin
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remediat, Yantai 264117, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Tianyu,Wang, Xin,Zhang, Qianqian,et al. Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,912:14.
APA Zhang, Tianyu.,Wang, Xin.,Zhang, Qianqian.,Yang, Dinglong.,Zhang, Xiaoli.,...&Zhao, Jianmin.(2024).Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians.SCIENCE OF THE TOTAL ENVIRONMENT,912,14.
MLA Zhang, Tianyu,et al."Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians".SCIENCE OF THE TOTAL ENVIRONMENT 912(2024):14.

入库方式： OAI收割

来源：烟台海岸带研究所

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